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Optimal choice of the number of treatments to be included in a clinical trial

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Stallard, Nigel, Posch, Martin, Friede, Tim, Koenig, F. (Franz) and Brannath, Werner (2009) Optimal choice of the number of treatments to be included in a clinical trial. Statistics in Medicine, Vol.28 (No.9). pp. 1321-1338. doi:10.1002/sim.3551

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Official URL: http://dx.doi.org/10.1002/sim.3551

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Abstract

It is common for a number of potentially effective treatments to be available for clinical evaluation. Limitations on resources mean that this inevitably leads to a decision as to how many, and which, treatments should be considered for inclusion in a clinical trial. This paper considers the problem of selection of possible treatments for inclusion in a phase III clinical trial. We assume that treatments will be compared using a standard frequentist hypothesis test, and propose a Bayesian decision-theoretic approach that leads to minimization of the total sample size of the trial subject to controlling the familywise type I error rate and the expected probability of rejecting at least one null hypothesis. The method is illustrated in the simplest situation, in which two experimental treatments could be included in the clinical trial, exploring the levels of evidence that are required to lead to an optimal trial that includes one or both of these treatments. Copyright (C) 2009 John Wiley & Sons, Ltd.

Item Type: Journal Article
Subjects: Q Science > QA Mathematics
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Clinical trials -- Design, Bayesian statistical decision theory, Therapeutics -- Testing, Drugs -- Effectiveness -- Evaluation, Drug development
Journal or Publication Title: Statistics in Medicine
Publisher: John Wiley & Sons Ltd.
ISSN: 0277-6715
Official Date: 30 April 2009
Dates:
DateEvent
30 April 2009Published
Volume: Vol.28
Number: No.9
Number of Pages: 18
Page Range: pp. 1321-1338
DOI: 10.1002/sim.3551
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: British Council (Austria)
Version or Related Resource: Stallard, N., Friede, T., Posch, M., Koenig, F. and Brannath, W. (2010), Correction. Statist. Med., 29: 614–615. doi: 10.1002/sim.3817

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