Abou Neel, Ensanya Ali, O'Dell, L. A., Chrzanowski, Wojciech, Smith, Mark E. and Knowles, Jonathan Campbell. (2009) Control of Surface Free Energy in Titanium Doped Phosphate Based Glasses by Co-Doping With Zinc. Journal of Biomedical Materials Research Part B - Applied Biomaterials, Vol.89B (No.2). pp. 392-407. ISSN 1552-4973

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Abstract

To significantly improve the biocompatibility of titanium doped phosphate based glasses, codoping with zinc has been attempted. This study investigated the effect of doping a quaternary 15Na(2)O:30CaO:5TiO(2):50P(2)O(5) glass with zinc oxide (1, 3, and 5 mol %) on bulk, structural, surface, and biological properties; the results were compared with glasses free from ZnO and/or TiO2. ZnO as adjunct to TiO2 was effective in changing density, interchain bond forces, degradation behavior, and ions released from the degrading glasses. Incorporation of both TiO2 and ZnO in T5Z1, T5Z3, and T5Z5 glasses reduced the level of Zn2+ release by two to three orders of magnitude compared with glasses containing ZnO only (Z5). P-31 NMR results for T5Z1, T5Z3, and T5Z5 glasses showed the presence of Q(3) species suggesting that the TiO2 is acting as a network former, and the phosphate network becomes slightly more connected with increasing ZnO incorporation. Regardless of their relative lower hydrophilicity and surface reactivity compared with the control glass free from TiO2 and ZnO (T0Z0), these glasses have significantly higher surface reactivity compared with Thermanox (R). This has been also reflected in the maintenance of >98% viable Osteoblasts, proliferation rate, and expression level of osteoblastic marker genes in a comparable manner to Thermanox (R) and T5 glasses, particularly T5Z1 and T5Z3 glasses. However, T0Z0 and Z5 glasses showed significantly reduced viability compared to Thermanox (R). Therefore, it can be concluded that ZnO doped titanium phosphate glasses, T5Z1 and T5Z3 in particular, can be promising substrates for bone tissue engineering applications. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 89B: 392-407, 2009

Item Type:	Journal Article
Subjects:	R Medicine
Divisions:	Faculty of Science > Physics
Journal or Publication Title:	Journal of Biomedical Materials Research Part B - Applied Biomaterials
Publisher:	Wiley-Liss
ISSN:	1552-4973
Official Date:	May 2009
Volume:	Vol.89B
Number:	No.2
Number of Pages:	16
Page Range:	pp. 392-407
Identification Number:	10.1002/jbm.b.31227
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/28098

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