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Exploring changes in treatment effects across design stages in adaptive trials
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Friede, Tim and Henderson, Robin. (2009) Exploring changes in treatment effects across design stages in adaptive trials. Pharmaceutical Statistics, Vol.8 (No.1). pp. 62-72. ISSN 1539-1604
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Official URL: http://dx.doi.org/10.1002/pst.332
Abstract
The recently published committee for Medicinal Products for Human Use reflection paper on flexible designs highlights a controversial issue regarding the interpretation of adaptive trials. The guideline suggests that a test for heterogeneity should he preplanned and if treatment effect estimates differ significantly between design stages then data collected be ore and after the interim analysis might not be combined in a formal analysis. In this paper we investigate error rates for such a procedure ill the presence of calendar-time effects. Furthermore, we present all alternative testing strategy based oil change point methods. In a simulation study we demonstrate that our procedure performs well in comparison to that suggested by the guideline. Copyright (C) 2008 John Wiley & Sons, Ltd.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica Q Science > QA Mathematics |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Pharmaceutical Statistics |
| Publisher: | John Wiley & Sons Ltd. |
| ISSN: | 1539-1604 |
| Date: | January 2009 |
| Volume: | Vol.8 |
| Number: | No.1 |
| Number of Pages: | 11 |
| Page Range: | pp. 62-72 |
| Identification Number: | 10.1002/pst.332 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/28193 |
Data sourced from Thomson Reuters' Web of Knowledge
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