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Evolution of pathogenicity in the Bacillus cereus group
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Didelot, Xavier, Barker, Margaret, Falush, Daniel and Priest, Fergus G. (2009) Evolution of pathogenicity in the Bacillus cereus group. Systematic and Applied Microbiology, Vol.32 (No.2). pp. 81-90. doi:10.1016/j.syapm.2009.01.001 ISSN 0723-2020.
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Official URL: http://dx.doi.org/10.1016/j.syapm.2009.01.001
Abstract
The Bacillus cereus group of bacteria comprises soil-dwelling saprophytes but on occasion these bacteria can cause a wide range of diseases in humans, including food poisoning, systemic infections and highly lethal forms of anthrax. While anthrax is almost invariably caused by strains from a single evolutionary lineage, Bacillus anthracis, variation in the virulence properties of strains from other lineages has not been fully addressed. Using multi-locus sequence data from 667 strains, we reconstructed the evolutionary history of the B. cereus group in terms of both clonal inheritance and recombination. The strains included 155 clinical isolates representing B. anthracis, and isolates from emetic and diarrhoeal food poisoning, septicaemia and related infections, wound, and lung infections. We confirmed the existence of three major clades and found that clinical isolates of B. cereus (with the exception of emetic toxin-producing strains) are evenly distributed between and within clades 1 and 2. B. anthracis in particular and emetic toxin-producing B. cereus show more clonal structure and are restricted to clade 1. Our characterization of the patterns of genetic exchange showed that there exist partial barriers to gene flow between the three clades. The pathogenic strains do not exhibit atypically high or low rates of recombination, consistent with the opportunistic nature of most pathogenic infections. However, there have been a large number of recent imports in clade I of strains from external origins, which is indicative of an on-going shift in gene-flow boundaries for this clade. (C) 2009 Elsevier GmbH. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||
| Journal or Publication Title: | Systematic and Applied Microbiology | ||||
| Publisher: | Urban und Fischer Verlag | ||||
| ISSN: | 0723-2020 | ||||
| Official Date: | April 2009 | ||||
| Dates: |
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| Volume: | Vol.32 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 81-90 | ||||
| DOI: | 10.1016/j.syapm.2009.01.001 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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