Miller, Michelle A., Dr., Strazzullo, Pasquale, Karanam, Sharada and Cappuccio, Francesco P.. (2009) Ethnic variation in levels of circulating IgG autoantibodies to oxidised low-density lipoprotein. Atherosclerosis, Vol.203 (No.1). pp. 126-136. ISSN 0021-9150

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Abstract

Background: Oxidised low-density lipoprotein (Ox-LDL) plays a key role in atherosclerosis. Our aim was to determine whether serum autoantibodies against Ox-LDL (Ab Ox-LDL) differ by ethnic group. Design and methods: Soluble serum Ab Ox-LDL levels were measured in 250 white (113 females), 169 African origin (91 females) and 196 South Asian (92 females) individuals from the Wandsworth Heart and Stroke Study (WHSS) population. All were free from coronary heart disease (CHID), stroke, other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. Results: There were no sex differences in levels of Ab Ox-LDL, but levels were higher in non-smokers (430 U/L [95% CI 471-596]) than in smokers (384 U/L [316-468]) (p < 0.009). Age- and sex-adjusted levels of Ab Ox-LDL were higher in people of African origin and South Asians compared to whites. This difference was maintained in South Asian women following adjustment for multiple risk factors (82% [21-175]; p=0.004). Ab Ox-LDL levels were negatively associated with serum triglycerides and positively associated with sVCAM-1. Conclusions: Higher IgG Ab to Ox-LDL are associated with higher levels of sVCAM-1 and, are elevated in female South Asian individuals who have an increased risk of atherosclerosis compared to whites. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Atherosclerosis
Publisher:	Elsevier Ireland Ltd.
ISSN:	0021-9150
Date:	March 2009
Volume:	Vol.203
Number:	No.1
Number of Pages:	11
Page Range:	pp. 126-136
Identification Number:	10.1016/j.atherosclerosis.2008.05.053
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	British Heart Foundation, European Union, The Wellcome Trust, Wandsworth and South Thames Regional Health Authorities, NHS RD Directorate, British Heart Foundation, British Diabetic Association, The Stroke Association
Grant number:	PG/2001023, QLK1-CT-2000-00100
URI:	http://wrap.warwick.ac.uk/id/eprint/28258

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