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Strategies for the discovery of new natural products by genome mining

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Zerikly, Malek and Challis, Gregory L.. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem, Vol.10 (No.4). pp. 625-633. ISSN 1439-4227

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Official URL: http://dx.doi.org/10.1002/cbic.200800389

Abstract

Natural products have a very broad spectrum of applications. Many natural products are used clinically as antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive agents and are therefore of utmost importance for our society. When in the 1940s the golden age of antibiotics was ushered in, a "gold rush fever" of natural product discovery in the pharmaceutical industry ensued for many decades. However, the traditional process of discovering new bioactive natural products is generally long and laborious, and known natural products are frequently rediscovered. A mass-withdrawal of pharmaceutical companies from new natural product discovery and natural products research has thus occurred in recent years. In this article, the concept of genome mining for novel natural product discovery, which promises to provide a myriad of new bioactive natural compounds, is summarized and discussed. Genome mining for new natural product discovery exploits the huge and constantly increasing quantity of DNA sequence data from a wide variety of organisms that is accumulating in publicly accessible databases. Genes encoding enzymes likely to be involved in natural product biosynthesis can be readily located in sequenced genomes by use of computational sequence comparison tools. This information can be exploited in a variety of ways in the search for new bioactive natural products.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
Q Science > QP Physiology

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Genomics, Biosynthesis, Natural products, Peptides, Polyketides

Journal or Publication Title:

Chembiochem

Publisher:

Wiley - V C H Verlag GmbH & Co. KGaA

ISSN:

1439-4227

Official Date:

2 March 2009

Dates:

Date	Event
2 March 2009	Published

Volume:

Vol.10

Number:

No.4

Number of Pages:

Page Range:

pp. 625-633

Identification Number:

10.1002/cbic.200800389

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU)

Grant number:

BB/E008003/1 (BBSRC), EGH16081 (BBSRC), 816610 (BBSRC), MEIF-CT-2003-501686 (EU), 005224 (EU)

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