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Strategies for the discovery of new natural products by genome mining

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Zerikly, Malek and Challis, Gregory L.. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem, Vol.10 (No.4). pp. 625-633. ISSN 1439-4227

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Abstract

Natural products have a very broad spectrum of applications. Many natural products are used clinically as antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive agents and are therefore of utmost importance for our society. When in the 1940s the golden age of antibiotics was ushered in, a "gold rush fever" of natural product discovery in the pharmaceutical industry ensued for many decades. However, the traditional process of discovering new bioactive natural products is generally long and laborious, and known natural products are frequently rediscovered. A mass-withdrawal of pharmaceutical companies from new natural product discovery and natural products research has thus occurred in recent years. In this article, the concept of genome mining for novel natural product discovery, which promises to provide a myriad of new bioactive natural compounds, is summarized and discussed. Genome mining for new natural product discovery exploits the huge and constantly increasing quantity of DNA sequence data from a wide variety of organisms that is accumulating in publicly accessible databases. Genes encoding enzymes likely to be involved in natural product biosynthesis can be readily located in sequenced genomes by use of computational sequence comparison tools. This information can be exploited in a variety of ways in the search for new bioactive natural products.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Genomics, Biosynthesis, Natural products, Peptides, Polyketides
Journal or Publication Title: Chembiochem
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1439-4227
Official Date: 2 March 2009
Volume: Vol.10
Number: No.4
Number of Pages: 9
Page Range: pp. 625-633
Identification Number: 10.1002/cbic.200800389
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU)
Grant number: BB/E008003/1 (BBSRC), EGH16081 (BBSRC), 816610 (BBSRC), MEIF-CT-2003-501686 (EU), 005224 (EU)
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URI: http://wrap.warwick.ac.uk/id/eprint/28349

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