Rabbani, Naila and Thornalley, Paul J. (2009) Quantitation of markers of protein damage by glycation, oxidation, and nitration in peritoneal dialysis. In: 12th Congress of the International-Society-for-Peritoneal-Dialysis, Istanbul, Turkey, JUN 20-24, 2008. Published in: Peritoneal Dialysis International, Vol.29 (Suppl. 2). S51-S56.

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Abstract

Proteolysis products of proteins damaged by glycation, oxidation, and nitration-glycated, oxidized, and nitrated amino acids (glycation, oxidation, and nitration free adducts) - are waste products normally excreted in urine and cleared in peritoneal dialysate. Glucose degradation products in peritoneal dialysis (PD) fluids may increase protein damage, giving rise to increased protein glycation, oxidation, and nitration adduct residues of proteins and increased flux of glycation, oxidation, and nitration free adducts. Increased protein damage has been linked to mortality in end-stage renal disease. Reliable quantitation of markers for adducts of protein glycation, oxidation, and nitration is required for mechanistic studies and for morbidity and mortality risk analysis in PD patients. We review the available analytical techniques for such quantitation. Stable isotopic dilution analysis with tandem mass spectrometry is the "gold standard." This method needs to be applied further in the study of PD and to validate other techniques so that the effect of PD on the metabolism and clearance of damaged proteins and related products can be quantified, and so that best-practice fluid management can be established to minimize cardiovascular risk.

Item Type:	Conference Item (Speech)
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Peritoneal Dialysis International
Publisher:	Multimed Inc.
ISSN:	0896-8608
Date:	February 2009
Volume:	Vol.29
Number:	Suppl. 2
Number of Pages:	6
Page Range:	S51-S56
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Speech
Title of Event:	12th Congress of the International-Society-for-Peritoneal-Dialysis
Type of Event:	Conference
Location of Event:	Istanbul, Turkey
Date(s) of Event:	JUN 20-24, 2008
URI:	http://wrap.warwick.ac.uk/id/eprint/28371

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