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Requirement of Wnt/beta-catenin signaling in pronephric kidney development
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Lyons, Jon P., Miller, Rachel K., Zhou, Xiaolan, Weidinger, Gilbert, Deroo, Tom, Denayer, Tinneke, Park, Jae-Il, Ji, Hong, Hong, Ji Yeon, Li, Annette, Moon, Randall T., Jones, Elizabeth A., Vleminckx, Kris, Vize, Peter D. and McCrea, Pierre D. (2009) Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mechanisms of Development, Vol.126 (No.3-4). pp. 142-159. doi:10.1016/j.mod.2008.11.007
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Official URL: http://dx.doi.org/10.1016/j.mod.2008.11.007
Abstract
The pronephric kidney controls water and electrolyte balance during early fish and amphibian embryogenesis. Many Wnt signaling components have been implicated in kidney development. Specifically, in Xenopus pronephric development as well as the murine metanephroi, the secreted glycoprotein Wnt-4 has been shown to be essential for renal tubule formation. Despite the importance of Wnt signals in kidney organogenesis, little is known of the definitive downstream signaling pathway(s) that mediate their effects. Here we report that inhibition of Wnt/beta-catenin signaling within the pronephric field of Xenopus results in significant losses to kidney epithelial tubulogenesis with little or no effect on adjoining axis or somite development. We find that the requirement for Wnt/beta-catenin signaling extends throughout the pronephric primordium and is essential for the development of proximal and distal tubules of the pronephros as well as for the development of the duct and glomus. Although less pronounced than effects upon later pronephric tubule differentiation, inhibition of the Wnt/beta-catenin pathway decreased expression of early pronephric mesenchymal markers indicating it is also needed in early pronephric patterning. We find that upstream inhibition of Wnt/beta-catenin signals in zebrafish likewise reduces pronephric epithelial tubulogenesis. We also find that exogenous activation of Wnt/beta-catenin signaling within the Xenopus pronephric field results in significant tubulogenic losses. Together, we propose Wnt/beta-catenin signaling is required for pronephric tubule, duct and glomus formation in Xenopus laevis, and this requirement is conserved in zebrafish pronephric tubule formation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Journal or Publication Title: | Mechanisms of Development | ||||
| Publisher: | Elsevier Ireland Ltd | ||||
| ISSN: | 0925-4773 | ||||
| Official Date: | March 2009 | ||||
| Dates: |
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| Volume: | Vol.126 | ||||
| Number: | No.3-4 | ||||
| Number of Pages: | 18 | ||||
| Page Range: | pp. 142-159 | ||||
| DOI: | 10.1016/j.mod.2008.11.007 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Institutes of Health (NIH), March of Dimes, Institutional Research and BSRG Grants, NIH Training Grant, American Legion Auxiliary Fellowship, UT-Torch Training Grant, NIH Training Grant, NIH Postdoctoral NRSA, Odyssey Program, The Theodore N. Law Endowment for Scientific Achievement at The University of Texas, Anderson Cancer Center, UTMDACC NCI Core | ||||
| Grant number: | R01 (GM052112), 1-FY-07-461-01, DE015355 to J.P.L., HD07325, DK082145, CA-16672 |
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