McQuigg, M., Brown, J. E., Broom, J., Laws, R. A., Reckless, J. P. D., Noble, P. A., Kumar, Sudhesh, McCombie, E. L., Lean, M. E. J., Lyons, F. G., Frost, G. S., Quinn, M. F., Barth, J. H., Haynes, S. M., Finer, N., Haslam, D. W., Ross, H. M., Hole, D. J. and Radziwonik, S. (2008) The Counterweight programme: Prevalence of CVD risk factors by body mass index and the impact of 10% weight change. Obesity Research & Clinical Practice, Vol.2 (No.1). pp. 15-27. ISSN 1871-403X

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Abstract

Objectives: To examine relationships between body mass index (BMI), prevalence of physician-recorded cardiovascular disease (CVD) risk factors in primary care, and changes in risk with 10% weight change. Methods: The Counterweight Project conducted a baseline cross-sectional survey of medical records of 6150 obese (BMI >= 30 kg/ml), 1150 age- and sex-matched overweight (BMI 25 to <30kg/m(2)), and 1150 age- and sex-matched normal weight (BMI 18.5 to <25kg/m(2)) controls, in primary care. Data were collected for the previous 18 months to examine BMI and disease prevalence, and then modelled to show the potential effect of 10% weight loss or gain on risk. Results: Obese patients develop more CVD risk factors than normal weight controls. BMI >= 40 kg/m(2) exhibits increased prevalence of type 2 diabetes mellitus (DM), odds ratio (OR) men: 6.16 (p < 0.001); women: 7.82 (p < 0.001) and hypertension OR men: 5.51 (p < 0.001); women: 4.16 (p < 0.001). Dyslipidaemia peaked around BMI 35 to <37.5 kg/m(2), OR men: 3.26 (p < 0.001); women 3.76 (p < 0.001) and CVD at BMI 37.5 2 to <40 kg/m(2) in men, OR 4.48 (p < 0.001) and BMI >= 40 kg/m(2) in women, OR 3.98 (P < 0.001). A 10% weight loss from the sample mean of 32.5 kg/m(2) reduced the OR for type 2 DM by 30% and CVD by 20%, while 10% weight gain increased type 2 DM risk by more than 35% and CVD by 20%. Conclusion: Obesity plays a fundamental role in CVD risk, which is reduced with weight loss. Weight management intervention strategies should be a public health priority to reduce the burden of disease in the population. (C) 2008 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Obesity Research & Clinical Practice
Publisher:	Elsevier BV
ISSN:	1871-403X
Date:	March 2008
Volume:	Vol.2
Number:	No.1
Number of Pages:	13
Page Range:	pp. 15-27
Identification Number:	10.1016/j.orcp.2008.01.002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/28455

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