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Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses
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Pickup, D. M., Moss, R. M., Qiu, D., Newport, R. J., Valappil, S. P., Knowles, J. C. and Smith, Mark E.. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, Vol.130 (No.6). Article no. 064708. ISSN 0021-9606
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Official URL: http://dx.doi.org/10.1063/1.3076057
Abstract
Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QC Physics |
| Divisions: | Administration > Vice Chancellor's Office Faculty of Science > Physics |
| Journal or Publication Title: | Journal of Chemical Physics |
| Publisher: | American Institute of Physics |
| ISSN: | 0021-9606 |
| Date: | 14 February 2009 |
| Volume: | Vol.130 |
| Number: | No.6 |
| Number of Pages: | 7 |
| Page Range: | Article no. 064708 |
| Identification Number: | 10.1063/1.3076057 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | STFC |
| Grant number: | EP/C000714, EP/C000633, GR/T21080 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/28466 |
Data sourced from Thomson Reuters' Web of Knowledge
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