Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses
Pickup, D. M., Moss, R. M., Qiu, D., Newport, R. J., Valappil, S. P., Knowles, J. C. and Smith, Mark E.. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, Vol.130 (No.6). Article no. 064708. ISSN 0021-9606Full text not available from this repository.
Official URL: http://dx.doi.org/10.1063/1.3076057
Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.
|Item Type:||Journal Article|
|Subjects:||Q Science > QC Physics|
|Divisions:||Administration > Vice Chancellor's Office
Faculty of Science > Physics
|Journal or Publication Title:||Journal of Chemical Physics|
|Publisher:||American Institute of Physics|
|Date:||14 February 2009|
|Number of Pages:||7|
|Page Range:||Article no. 064708|
|Access rights to Published version:||Restricted or Subscription Access|
|Grant number:||EP/C000714, EP/C000633, GR/T21080|
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