The Library
Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses
Tools
Pickup, D. M., Moss, R. M., Qiu, D., Newport, R. J., Valappil, S. P., Knowles, J. C. and Smith, Mark E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, Vol.130 (No.6). Article no. 064708. doi:10.1063/1.3076057 ISSN 0021-9606.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1063/1.3076057
Abstract
Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QC Physics | ||||
Divisions: | Administration > University Executive Office Faculty of Science, Engineering and Medicine > Science > Physics |
||||
Journal or Publication Title: | Journal of Chemical Physics | ||||
Publisher: | American Institute of Physics | ||||
ISSN: | 0021-9606 | ||||
Official Date: | 14 February 2009 | ||||
Dates: |
|
||||
Volume: | Vol.130 | ||||
Number: | No.6 | ||||
Number of Pages: | 7 | ||||
Page Range: | Article no. 064708 | ||||
DOI: | 10.1063/1.3076057 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | STFC | ||||
Grant number: | EP/C000714, EP/C000633, GR/T21080 |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |