Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N '-tosyl-1,2-ethanediamine ligands
Martins, Jose E. D., Morris, David J. and Wills, Martin. (2009) Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N '-tosyl-1,2-ethanediamine ligands. Tetrahedron Letters, Vol.50 (No.6). pp. 688-692. ISSN 0040-4039Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.11.101
The combination of an enantiomerically pure N'-alkylated derivative of N-4-toluenesulfonyl-1,2-diphenylethane-1,2-diamine (TsDPEN) with iridium trichloride results in the formation of a catalyst with high selectivity for ketone hydrogenation. Products with enantiomeric excesses of up to 84% were formed. The best results were obtained using a ligand with an n-alkyl chain and ortho-substituted acetophenone derivatives and other hindered derivatives. (C) 2008 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Hydrogenation, Ketones, Iridium, Catalysis, Acetophenone, Ligands|
|Journal or Publication Title:||Tetrahedron Letters|
|Official Date:||11 February 2009|
|Number of Pages:||5|
|Page Range:||pp. 688-692|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES)|
|Grant number:||EP/D031168/1 (EPSRC)|
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