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Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N '-tosyl-1,2-ethanediamine ligands
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Martins, Jose E. D., Morris, David J., 1974- and Wills, Martin. (2009) Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N '-tosyl-1,2-ethanediamine ligands. Tetrahedron Letters, Vol.50 (No.6). pp. 688-692. ISSN 0040-4039
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.11.101
Abstract
The combination of an enantiomerically pure N'-alkylated derivative of N-4-toluenesulfonyl-1,2-diphenylethane-1,2-diamine (TsDPEN) with iridium trichloride results in the formation of a catalyst with high selectivity for ketone hydrogenation. Products with enantiomeric excesses of up to 84% were formed. The best results were obtained using a ligand with an n-alkyl chain and ortho-substituted acetophenone derivatives and other hindered derivatives. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Hydrogenation, Ketones, Iridium, Catalysis, Acetophenone, Ligands |
| Journal or Publication Title: | Tetrahedron Letters |
| Publisher: | Elsevier |
| ISSN: | 0040-4039 |
| Date: | 11 February 2009 |
| Volume: | Vol.50 |
| Number: | No.6 |
| Number of Pages: | 5 |
| Page Range: | pp. 688-692 |
| Identification Number: | 10.1016/j.tetlet.2008.11.101 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
| Grant number: | EP/D031168/1 (EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/28502 |
Data sourced from Thomson Reuters' Web of Knowledge
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