The Library
Beyond p-values: averaged and reproducible evidence in fMRI experiments
Tools
Tools
Tools
Liou, Michelle, Su, Hong-Ren, Savostyanov, Alexander N., Lee, Juin-Der, Aston, John A. D., Chuang, Cheng-Hung and Cheng, Philip E. (2009) Beyond p-values: averaged and reproducible evidence in fMRI experiments. Psychophysiology, Vol.46 (No.2). pp. 367-378. doi:10.1111/j.1469-8986.2008.00780.x ISSN 0048-5772.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1111/j.1469-8986.2008.00780.x
Abstract
In functional magnetic resonance imaging studies, there might exist activation regions routinely involved in experimental sessions, but modest in response magnitude. These regions may not be easily detectable by the conventional p-value approach using a rigid threshold. With particular reference to the reproducibility analysis method proposed in Liou and colleagues, this study presents some within- and between-subject brain-activation patterns that are replicable between experimental modalities, and robust to the method used for generating the patterns. There is a neurophysiological basis behind these reproducible patterns, and the conventional p-value approach using averaged data across subjects might not suggest the complete patterns. For example, recent studies based on the group-averaged data showed a task-induced deactivation in the precuneus and posterior cingulate, but our reproducibility analysis suggests both increased and decreased responses in the two regions. The increased responses localize in these regions with differentially distributed patterns for individual subjects and for different experimental tasks. In this study, we discuss the neurophysiological basis of the reproducible patterns and propose some applications of our research findings to scientific and clinical studies.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Q Science > QP Physiology |
||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||
| Journal or Publication Title: | Psychophysiology | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISSN: | 0048-5772 | ||||
| Official Date: | March 2009 | ||||
| Dates: |
|
||||
| Volume: | Vol.46 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 367-378 | ||||
| DOI: | 10.1111/j.1469-8986.2008.00780.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Science Council (Taiwan) | ||||
| Grant number: | NSC96-2413-H-001-001-MY3 |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
