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Ru(II) complexes of N-Alkylated TsDPEN ligands in asymmetric transfer hydrogenation of ketones and imines
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Martins, Jose E. D., Clarkson, Guy J. and Wills, Martin (2009) Ru(II) complexes of N-Alkylated TsDPEN ligands in asymmetric transfer hydrogenation of ketones and imines. Organic Letters, Vol.11 (No.4). pp. 847-850. doi:10.1021/ol802801p
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Official URL: http://dx.doi.org/10.1021/ol802801p
Abstract
N-Alkylated TsDPEN derivatives bearing a small alkyl group act as highly efficient ligands in Ru(II) complexes for the asymmetric transfer hydrogenation of imines and ketones. A larger alkyl group serves to significantly reduce the activity of the catalyst; however, high enantiomeric excesses are still obtained. An X-ray crystal structure of the N-benzyl derivative reveals a conformation that permits hydrogen transfer through a six-membered transition state. A transition state structure for the imine reduction process is proposed.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Hydrogenation, Catalysis, Ketones, Imines, Carbonyl compounds, Ruthenium | ||||
| Journal or Publication Title: | Organic Letters | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 1523-7060 | ||||
| Official Date: | 19 February 2009 | ||||
| Dates: |
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| Volume: | Vol.11 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 847-850 | ||||
| DOI: | 10.1021/ol802801p | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
| Grant number: | EP/F019424/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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