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Ru(II) complexes of N-Alkylated TsDPEN ligands in asymmetric transfer hydrogenation of ketones and imines
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Martins, Jose E. D., Clarkson, Guy J. and Wills, Martin (2009) Ru(II) complexes of N-Alkylated TsDPEN ligands in asymmetric transfer hydrogenation of ketones and imines. Organic Letters, Vol.11 (No.4). pp. 847-850. doi:10.1021/ol802801p ISSN 1523-7060.
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Official URL: http://dx.doi.org/10.1021/ol802801p
Abstract
N-Alkylated TsDPEN derivatives bearing a small alkyl group act as highly efficient ligands in Ru(II) complexes for the asymmetric transfer hydrogenation of imines and ketones. A larger alkyl group serves to significantly reduce the activity of the catalyst; however, high enantiomeric excesses are still obtained. An X-ray crystal structure of the N-benzyl derivative reveals a conformation that permits hydrogen transfer through a six-membered transition state. A transition state structure for the imine reduction process is proposed.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Hydrogenation, Catalysis, Ketones, Imines, Carbonyl compounds, Ruthenium | ||||
Journal or Publication Title: | Organic Letters | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 1523-7060 | ||||
Official Date: | 19 February 2009 | ||||
Dates: |
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Volume: | Vol.11 | ||||
Number: | No.4 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 847-850 | ||||
DOI: | 10.1021/ol802801p | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | EP/F019424/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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