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Osmium arenes : a new class of potential anti-cancer agents
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van Rijt, Sabine H., Peacock, Anna F. A. and Sadler, P. J. (2009) Osmium arenes : a new class of potential anti-cancer agents. In: Bonetti, Andrea, MD and Leone, Roberto and Muggia, Franco M. and Howell, Stephen B., 1944-, (eds.) Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications. Cancer drug discovery and development . Totowa, N.J. : London: Humana : Springer [distributor], pp. 73-79. ISBN 978-1-60327-458-6
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Official URL: http://dx.doi.org/10.1007/978-1-60327-459-3_10
Abstract
Our studies of half-sandwich osmium(II) arene complexes of the type [(eta(6)-arene)Os(XY)Z] show that hydrolysis of the Os-Z (Z = Cl) bond and degree of formation of biologically inactive hydroxo-bridged dimers can be controlled by the choice of the chelated ligand XY. The chemistry and cancer-cell cytotoxicity of complexes containing N,N-, N,O-, or O,O-chelating ligands are compared and contrasted. The wide kinetic timescales of the reactions of these osmium complexes are notable and promising for the design of novel anti-cancer agents.
| Item Type: | Book Item |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Aromatic compounds -- Therapeutic use, Osmium compounds -- Therapeutic use, Organometallic compounds -- Therapeutic use, Antineoplastic agents, Hydrolysis |
| Series Name: | Cancer drug discovery and development |
| Journal or Publication Title: | Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications |
| Publisher: | Humana : Springer [distributor] |
| Place of Publication: | Totowa, N.J. : London |
| ISBN: | 978-1-60327-458-6 |
| Book Title: | Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications |
| Editor: | Bonetti, Andrea, MD and Leone, Roberto and Muggia, Franco M. and Howell, Stephen B., 1944- |
| Date: | 2009 |
| Number of Pages: | 383 |
| Page Range: | pp. 73-79 |
| Identification Number: | 10.1007/978-1-60327-459-3_10 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Title of Event: | 10th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy |
| Location of Event: | Verona, ITALY |
| Date(s) of Event: | DEC, 2007 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/28546 |
Data sourced from Thomson Reuters' Web of Knowledge
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