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Neural correlates of executive function and working memory in the 'at-risk mental state'
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Broome, Matthew R., Matthiasson, Pall, Fusar-Poli, Paolo, Woolley, James B., Johns, Louise C., Tabraham, Paul, Bramon, Elvira, Valmaggia, Lucia, Williams, Steven C. R., Brammer, Michael J., Chitnis, Xavier and McGuire, Philip (2009) Neural correlates of executive function and working memory in the 'at-risk mental state'. British Journal of Psychiatry, Vol.194 (No.1). pp. 25-33. doi:10.1192/bjp.bp.107.046789
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Official URL: http://dx.doi.org/10.1192/bjp.bp.107.046789
Abstract
Background
People with prodromal symptoms have a very high risk of developing psychosis.
Aims
To use functional magnetic resonance imaging to examine the neurocognitive basis of this Vulnerability.
Method
Cross-sectional comparison of regional activation in individuals with art 'at-risk mental state' (at-risk group: n=17), patients with first-episode schizophreniform psychosis (psychosis group: n=10) and healthy volunteers (controls: n=15) during an overt verbal fluency task and an N-back working memory task.
Results
A similar pattern of between-group differences in activation was evident across both tasks. Activation in the at-risk group was intermediate relative to that in controls and the psychosis group in the inferior frontal and anterior cingulate cortex during the verbal fluency task and in the inferior frontal, dorsolateral prefrontal and parietal cortex during the N-back task.
Conclusions
The at-risk mental state is associated with abnormalities of regional brain function that are qualitatively similar to, but less severe than, those in patients who have recently presented with psychosis.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | British Journal of Psychiatry | ||||
| Publisher: | Royal College of Psychiatrists | ||||
| ISSN: | 0007-1250 | ||||
| Official Date: | January 2009 | ||||
| Dates: |
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| Volume: | Vol.194 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 25-33 | ||||
| DOI: | 10.1192/bjp.bp.107.046789 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Guy's and St Thomas' Charitable Foundation, South London and Maudsley NHS Trust |
Data sourced from Thomson Reuters' Web of Knowledge
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