The effect of lubrication on density distributions of roller compacted ribbons
Miguelez-Moran, A. M., Wu, C. -Y. and Seville, J. P. K. (Jonathan P. K.). (2008) The effect of lubrication on density distributions of roller compacted ribbons. International Journal of Pharmaceutics, Vol.362 (No.1-2). pp. 52-59. ISSN 0378-5173Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ijpharm.2008.06.009
Roller compaction is a continuous dry granulation process for producing free flowing granules in order to increase the bulk density and uniformity of pharmaceutical formulations. It is a complicated process due to the diversity of powder blends and processing parameters involved. The properties of the produced ribbon are dominated by a number of factors, such as the powder properties. friction, roll speed, roll gap, feeding mechanisms and feeding speed, which consequently determine the properties of the granules (size distribution, density and flow behaviour). It is hence important to understand the influence of these factors on the ribbon properties. in this study, an instrumented roller press developed at the University of Birmingham is used to investigate the effect of lubrication on the density distribution of the ribbons. Three different cases are considered: (1) no lubrication, (2) lubricated press. in which the side cheek plates of the roller press are lubricated, and (3) lubricated powder, for which a lubricant is mixed into the powder. In addition, how the powders are fed into the entry region of the roller press and its influence on ribbon properties are also investigated. It is found that the method of feeding the powder into the roller press plays a crucial role in determining the homogeneity of the ribbon density. For the roller press used in this Study, a drag angle (i.e., the angle formed when the powder is dragged into the roller press) is introduced to characterise the powder flow pattern in the feeding hopper. It is shown that a sharper drag angle results in a more heterogeneous ribbon. In addition, the average ribbon density depends upon the peak pressure and nip angle. The higher the peak pressure and nip angle are, the higher the average ribbon density is. Furthermore, the densification behaviour of the powder during roller compaction is compared to that during die compaction. It has been shown that the densification behaviour during these two processes is similar if the ribbons and the tablets have the same thickness. (C) 2008 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Faculty of Science > Engineering|
|Journal or Publication Title:||International Journal of Pharmaceutics|
|Publisher:||Elsevier Science BV|
|Date:||1 October 2008|
|Number of Pages:||8|
|Page Range:||pp. 52-59|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC)|
|Grant number:||EP/C545230 (EPSRC), EP/C545249 (EPSRC)|
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