Photoactive trans ammine/amine diazido platinum(IV) complexes
Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J.. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. ISSN 0020-1693Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ica.2008.02.039
The synthesis and characterisation of eight new octahedral Pt-IV complexes of the type trans, trans, trans-[Pt(N-3)(2)(OH)(2)(NH3)(Am)] where Am = methylamine (2), ethylamine (4), thiazole (6), 2-picoline (8), 3-picoline (10), 4-picoline (12), cyclohexylamine (14), and quinoline (16) are reported, including the X-ray crystal structures of complexes 2, 8, and 14 as well as that of two of the precursor Pt-II complexes (trans-[ Pt(N-3)(2)(NH3)(methylamine)] (1) and trans-[Pt(N-3)(2)(NH3)(cyclohexylamine)](13)). Irradiation with UVA light rapidly induces loss in intensity of the azide-to-Pt-IV charge-transfer bands and gives rise to photoreduction of platinum. These complexes have potential for use as photoactivated anticancer agents. (C) 2008 Elsevier B. V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Photochemistry, Azides, Platinum, X-ray crystallography, Antineoplastic agents|
|Journal or Publication Title:||Inorganica Chimica Acta|
|Publisher:||Elsevier Science SA|
|Official Date:||20 February 2009|
|Number of Pages:||9|
|Page Range:||pp. 811-819|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), Scottish Enterprise, European Cooperation in the Field of Scientific and Technical Research (Organization)|
 P.J. Bednarski, F.S. Mackay, P.J. Sadler, Anticancer Agents Med.
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