Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J.. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. ISSN 0020-1693

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Abstract

The synthesis and characterisation of eight new octahedral Pt-IV complexes of the type trans, trans, trans-[Pt(N-3)(2)(OH)(2)(NH3)(Am)] where Am = methylamine (2), ethylamine (4), thiazole (6), 2-picoline (8), 3-picoline (10), 4-picoline (12), cyclohexylamine (14), and quinoline (16) are reported, including the X-ray crystal structures of complexes 2, 8, and 14 as well as that of two of the precursor Pt-II complexes (trans-[ Pt(N-3)(2)(NH3)(methylamine)] (1) and trans-[Pt(N-3)(2)(NH3)(cyclohexylamine)](13)). Irradiation with UVA light rapidly induces loss in intensity of the azide-to-Pt-IV charge-transfer bands and gives rise to photoreduction of platinum. These complexes have potential for use as photoactivated anticancer agents. (C) 2008 Elsevier B. V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Photochemistry, Azides, Platinum, X-ray crystallography, Antineoplastic agents
Journal or Publication Title:	Inorganica Chimica Acta
Publisher:	Elsevier Science SA
ISSN:	0020-1693
Date:	20 February 2009
Volume:	Vol.362
Number:	No.3
Number of Pages:	9
Page Range:	pp. 811-819
Identification Number:	10.1016/j.ica.2008.02.039
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Scottish Enterprise, European Cooperation in the Field of Scientific and Technical Research (Organization)
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URI:	http://wrap.warwick.ac.uk/id/eprint/28601

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