Whitelam, Stephen, Rogers, Carl, Pasqua, Andrea, Paavola, Chad, Trent, Jonathan and Geissler, Phillip L.. (2009) The impact of conformational fluctuations on self-assembly: cooperative aggregation of archaeal chaperonin proteins. Nano Letters, Vol.9 (No.1). pp. 292-297. ISSN 1530-6984

Full text not available from this repository.

Abstract

Protein complexes called rosettasomes self-assemble in solution to form large-scale filamentous and planar structures. The relative abundance of these aggregates varies abruptly with environmental conditions and sample composition. Our simulations of a model of patchy nanoparticles can reproduce this sharp crossover, but only if particles are allowed to switch between two internal states favoring different geometries of local binding. These results demonstrate how local conformational adaptivity can fundamentally influence the cooperativity of pattern-forming dynamics.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science > Centre for Systems Biology
Journal or Publication Title:	Nano Letters
Publisher:	American Chemical Society
ISSN:	1530-6984
Date:	January 2009
Volume:	Vol.9
Number:	No.1
Number of Pages:	6
Page Range:	pp. 292-297
Identification Number:	10.1021/nl8029306
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	United States. Dept. of Energy, BioSim European Union Network of Excellence, NIH Molecular Biophysics Training, Science Research Investment Fund
Grant number:	DE-AC02-05CH11231, LSHB-CT-2004-005137, T32GM08295
URI:	http://wrap.warwick.ac.uk/id/eprint/28672

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item