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The impact of conformational fluctuations on self-assembly: cooperative aggregation of archaeal chaperonin proteins
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Whitelam, Stephen, Rogers, Carl, Pasqua, Andrea, Paavola, Chad, Trent, Jonathan and Geissler, Phillip L. (2009) The impact of conformational fluctuations on self-assembly: cooperative aggregation of archaeal chaperonin proteins. Nano Letters, Vol.9 (No.1). pp. 292-297. doi:10.1021/nl8029306 ISSN 1530-6984.
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Official URL: http://dx.doi.org/10.1021/nl8029306
Abstract
Protein complexes called rosettasomes self-assemble in solution to form large-scale filamentous and planar structures. The relative abundance of these aggregates varies abruptly with environmental conditions and sample composition. Our simulations of a model of patchy nanoparticles can reproduce this sharp crossover, but only if particles are allowed to switch between two internal states favoring different geometries of local binding. These results demonstrate how local conformational adaptivity can fundamentally influence the cooperativity of pattern-forming dynamics.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry T Technology T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
| Journal or Publication Title: | Nano Letters | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 1530-6984 | ||||
| Official Date: | January 2009 | ||||
| Dates: |
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| Volume: | Vol.9 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 292-297 | ||||
| DOI: | 10.1021/nl8029306 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | United States. Dept. of Energy, BioSim European Union Network of Excellence, NIH Molecular Biophysics Training, Science Research Investment Fund | ||||
| Grant number: | DE-AC02-05CH11231, LSHB-CT-2004-005137, T32GM08295 |
Data sourced from Thomson Reuters' Web of Knowledge
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