Bland, Rosemary, Molostvov, Guerman, Bennett, Jeanette and Zehnder, Daniel. (2008) Calcium sensing receptor mediated signaling in human vascular smooth muscle cells. Journal of Bone and Mineral Research, Vol.23 . S423-S424. ISSN 0884-0431

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Abstract

Vascular smooth muscle cells play a pivotal role in the pathogenesis of medial
calcification. We have recently demonstrated expression of the calcium sensing receptor
(CaSR) in human aortic smooth muscle cells (HAoSMC) and human arteries and
demonstrated a correlation between CaSR expression and medial calcification. Here we have
examined downstream CaSR-mediated signaling pathways in HAoSMC and investigated the
role of the CaSR in regulating HAoSMC proliferation and apoptosis.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine
Divisions:	Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Vascular smooth muscle -- Physiology, Calcium -- Receptors, Calcium -- Physiological effect, Cellular signal transduction
Journal or Publication Title:	Journal of Bone and Mineral Research
Publisher:	Wiley-Blackwell Publishing, Inc.
ISSN:	0884-0431
Official Date:	September 2008
Dates:	Date Event September 2008 UNSPECIFIED
Volume:	Vol.23
Number of Pages:	1
Page Range:	S423-S424
Status:	Peer Reviewed
Publication Status:	Published
Description:	Abstracts of the 30th Annual Meeting of the American Society for Bone and Mineral Research
Funder:	Coventry Kidney Research Fund, Coventry and Warwickshire Kidney Patient Association
Version or Related Resource:	Paper presented at: 30th Annual Meeting of the American Society for Bone and Mineral Research, Montreal, Canada, Sep 12-16, 2008
Type of Event:	Conference
URI:	http://wrap.warwick.ac.uk/id/eprint/28799

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