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Calcium sensing receptor mediated signaling in human vascular smooth muscle cells
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Bland, Rosemary, Molostvov, Guerman, Bennett, Jeanette and Zehnder, Daniel (2008) Calcium sensing receptor mediated signaling in human vascular smooth muscle cells. Journal of Bone and Mineral Research, Vol.23 . S423-S424. ISSN 0884-0431.
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Abstract
Vascular smooth muscle cells play a pivotal role in the pathogenesis of medial
calcification. We have recently demonstrated expression of the calcium sensing receptor
(CaSR) in human aortic smooth muscle cells (HAoSMC) and human arteries and
demonstrated a correlation between CaSR expression and medial calcification. Here we have
examined downstream CaSR-mediated signaling pathways in HAoSMC and investigated the
role of the CaSR in regulating HAoSMC proliferation and apoptosis.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Vascular smooth muscle -- Physiology, Calcium -- Receptors, Calcium -- Physiological effect, Cellular signal transduction | ||||
| Journal or Publication Title: | Journal of Bone and Mineral Research | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISSN: | 0884-0431 | ||||
| Official Date: | September 2008 | ||||
| Dates: |
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| Volume: | Vol.23 | ||||
| Number of Pages: | 1 | ||||
| Page Range: | S423-S424 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Description: | Abstracts of the 30th Annual Meeting of the American Society for Bone and Mineral Research |
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| Funder: | Coventry Kidney Research Fund, Coventry and Warwickshire Kidney Patient Association | ||||
| Version or Related Resource: | Paper presented at: 30th Annual Meeting of the American Society for Bone and Mineral Research, Montreal, Canada, Sep 12-16, 2008 | ||||
| Type of Event: | Conference |
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