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Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction
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Cariou, Claire C. A., Clarkson, Guy J. and Shipman, Michael (2008) Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction. The Journal of Organic Chemistry, Vol.73 (No.24). pp. 9762-9764. doi:10.1021/jo801664g
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Official URL: http://dx.doi.org/10.1021/jo801664g
Abstract
2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Lactams -- Synthesis, Chemical reactions, Beta lactam antibiotics -- Synthesis | ||||
| Journal or Publication Title: | The Journal of Organic Chemistry | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 0022-3263 | ||||
| Official Date: | 19 December 2008 | ||||
| Dates: |
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| Volume: | Vol.73 | ||||
| Number: | No.24 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 9762-9764 | ||||
| DOI: | 10.1021/jo801664g | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
| Grant number: | EP/D035384/1 (EPSRC), EP/C007999/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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