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Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction
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Cariou, Claire C. A., Clarkson, Guy J. and Shipman, Michael (2008) Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction. The Journal of Organic Chemistry, Vol.73 (No.24). pp. 9762-9764. doi:10.1021/jo801664g ISSN 0022-3263.
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Official URL: http://dx.doi.org/10.1021/jo801664g
Abstract
2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Lactams -- Synthesis, Chemical reactions, Beta lactam antibiotics -- Synthesis | ||||
Journal or Publication Title: | The Journal of Organic Chemistry | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 0022-3263 | ||||
Official Date: | 19 December 2008 | ||||
Dates: |
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Volume: | Vol.73 | ||||
Number: | No.24 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 9762-9764 | ||||
DOI: | 10.1021/jo801664g | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | EP/D035384/1 (EPSRC), EP/C007999/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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