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Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction

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Cariou, Claire C. A., Clarkson, Guy J. and Shipman, Michael (2008) Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction. The Journal of Organic Chemistry, Vol.73 (No.24). pp. 9762-9764. doi:10.1021/jo801664g ISSN 0022-3263.

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Official URL: http://dx.doi.org/10.1021/jo801664g

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Abstract

2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Lactams -- Synthesis, Chemical reactions, Beta lactam antibiotics -- Synthesis
Journal or Publication Title: The Journal of Organic Chemistry
Publisher: American Chemical Society
ISSN: 0022-3263
Official Date: 19 December 2008
Dates:
DateEvent
19 December 2008Published
Volume: Vol.73
Number: No.24
Number of Pages: 3
Page Range: pp. 9762-9764
DOI: 10.1021/jo801664g
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/D035384/1 (EPSRC), EP/C007999/1 (EPSRC)

Data sourced from Thomson Reuters' Web of Knowledge

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