The Library
Rotavirus within day care centres in Oxfordshire, UK : characterization of partial immunity
Tools
White, Lisa J., Buttery, J., Cooper, Ben S., Nokes, D. James and Medley, Graham (2008) Rotavirus within day care centres in Oxfordshire, UK : characterization of partial immunity. Journal of The Royal Society Interface, Vol.5 (No.29). pp. 1481-1490. doi:10.1098/rsif.2008.0115 ISSN 1742-5689.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1098/rsif.2008.0115
Abstract
Repeated measures data for rotavirus infection in children within 14 day care centres (DCCs) in the Oxfordshire area, UK, are used to explore aspects of rotavirus transmission and immunity. A biologically realistic model for the transmission of infection is presented as a set of probability models suitable for application to the data. Two transition events are modelled separately: incidence and recovery. The complexity of the underlying mechanistic model is reflected in the choice of the fixed variables in the probability models. Parameter estimation was carried out using a Bayesian Markov chain Monte Carlo method. We use the parameter estimates obtained to build a pro. le of the natural history of rotavirus reinfection in an individual child. We infer that rotavirus transmission in children in DCCs is dependent on the DCC prevalence, with symptomatic infection of longer duration, but no more infectious per day of infectious period, than asymptomatic infection. There was evidence that a recent previous infection reduces the risk of disease and, to a lesser extent, reinfection, but not duration of infection. The results provide evidence that partial immunity to rotavirus infection develops over several time scales.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QA Mathematics Q Science > QR Microbiology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Rotavirus infections -- Case studies, Rotavirus infections -- Transmission -- Mathematical models, Immunity, Markov processes, Monte Carlo method | ||||
Journal or Publication Title: | Journal of The Royal Society Interface | ||||
Publisher: | The Royal Society Publishing | ||||
ISSN: | 1742-5689 | ||||
Official Date: | 6 December 2008 | ||||
Dates: |
|
||||
Volume: | Vol.5 | ||||
Number: | No.29 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 1481-1490 | ||||
DOI: | 10.1098/rsif.2008.0115 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Wellcome Trust (London, England), Fundação Calouste Gulbenkian (FCG), Fundação para a Ciência e a Tecnologia (FCT), European Commission (EC), NHS Executive. South East | ||||
Grant number: | 061584 (WT), 076278 (WT), MEXT-CT-2004-14338 (EC), SPGS769 (NHS) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |