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Albumin as a zinc carrier : properties of its high-affinity zinc-binding site

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Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317

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Official URL: http://dx.doi.org/10.1042/BST0361317

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Abstract

Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly understood, it is clear that in vertebrates the majority of plasma zinc (9-14 mu M; approx. 75-85%) is bound to serum albumin, constituting part of the so-called exchangeable pool. The binding of metal ions to serum albumins has been the subject of decades of studies, employing a multitude of techniques, but only recently has the identity and putative structure of the major zinc site on albumin been reported. intriguingly, this site is located at the interface between two domains, and involves two residues from each of domains I and it. Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent. Interactive binding of zinc and long-chain fatty acids to albumin may therefore have physiological implications.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Albumins, Zinc, Fatty acids, Cooperative binding (Biochemistry)
Journal or Publication Title: Biochemical Society Transactions
Publisher: Portland Press Ltd
ISSN: 0300-5127
Official Date: December 2008
Dates:
DateEvent
December 2008Published
Volume: Vol.36
Number: No.6
Number of Pages: 5
Page Range: pp. 1317-1321
DOI: 10.1042/BST0361317
Status: Peer Reviewed
Publication Status: Published
Funder: Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Delta Biotechnology Ltd (now Novozymes), European Commission (EC), British Petroleum Company (BP), Wellcome Trust (London, England), Wolfson Foundation

Data sourced from Thomson Reuters' Web of Knowledge

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