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Albumin as a zinc carrier : properties of its high-affinity zinc-binding site
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Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST0361317
Abstract
Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly understood, it is clear that in vertebrates the majority of plasma zinc (9-14 mu M; approx. 75-85%) is bound to serum albumin, constituting part of the so-called exchangeable pool. The binding of metal ions to serum albumins has been the subject of decades of studies, employing a multitude of techniques, but only recently has the identity and putative structure of the major zinc site on albumin been reported. intriguingly, this site is located at the interface between two domains, and involves two residues from each of domains I and it. Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent. Interactive binding of zinc and long-chain fatty acids to albumin may therefore have physiological implications.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Albumins, Zinc, Fatty acids, Cooperative binding (Biochemistry) | ||||
| Journal or Publication Title: | Biochemical Society Transactions | ||||
| Publisher: | Portland Press Ltd | ||||
| ISSN: | 0300-5127 | ||||
| Official Date: | December 2008 | ||||
| Dates: |
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| Volume: | Vol.36 | ||||
| Number: | No.6 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 1317-1321 | ||||
| DOI: | 10.1042/BST0361317 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Delta Biotechnology Ltd (now Novozymes), European Commission (EC), British Petroleum Company (BP), Wellcome Trust (London, England), Wolfson Foundation |
Data sourced from Thomson Reuters' Web of Knowledge
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