Increased plasma ghrelin following infliximab in Crohn's disease
Sung, E. Z. H., da Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Sanger, G. J. and Nwokolo, Chuka U.. (2009) Increased plasma ghrelin following infliximab in Crohn's disease. Alimentary Pharmacology and Therapeutic, Vol.29 (No.1). pp. 83-89. ISSN 0269-2813Full text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1365-2036.2008.03850.x
Background Ghrelin, a potent orexigenic peptide produced by the stomach, may be affected by circulating inflammatory mediators.
Aim To assess the effect of an anti-TNF alpha antibody on ghrelin in patients with Crohn's disease (CD).
Methods Fifteen patients with Crohn's receiving infliximab were studied before and 1 week after infusion. Following an overnight fast, blood was sampled before a meal and then every 20 min for 2 h. Total ghrelin and CRP were measured using ELISA. Acylated ghrelin and TNF alpha, IFN gamma, IL-1 beta and IL-6 were measured with bioplex. Harvey Bradshaw Activity Index was assessed.
Results Median (95% CI) 2-h integrated plasma total ghrelin increased from 162 (99-311) before infliximab to 200 (128-387) pg/mL h, (P = 0.02) after. Following infliximab, 20 min postmeal, median acylated ghrelin decreased from 50.3 (24-64) to 38.6 (26-82) pg/mL, (P = 0.04) thus reverting to a traditional meal related ghrelin curve. Median (range) disease activity decreased from 5 (2-28) before to 3 (0-22), (P = 0.0001) and Median (95% CI) TNFa decreased from 2.8 (1.89-4.48) to 1.31 (0.73-2.06) pg/mL (P = 0.002).
Conclusions Infliximab increases circulating total ghrelin by 25% in CD and restores the postprandial response of acylated ghrelin to food intake. Acylated and de-sacyl ghrelin remain unchanged, suggesting that an alternate isoform could be affected by infliximab.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RS Pharmacy and materia medica
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Crohn's disease -- Treatment -- Research, Ghrelin, Infliximab|
|Journal or Publication Title:||Alimentary Pharmacology and Therapeutic|
|Official Date:||1 January 2009|
|Number of Pages:||7|
|Page Range:||pp. 83-89|
|Access rights to Published version:||Restricted or Subscription Access|
1 Kojima M, Hosoda H, Date Y, Nakazato
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