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Increased plasma ghrelin following infliximab in Crohn's disease
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Sung, E. Z. H., da Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Sanger, G. J. and Nwokolo, Chuka U. (2009) Increased plasma ghrelin following infliximab in Crohn's disease. Alimentary Pharmacology and Therapeutic, Vol.29 (No.1). pp. 83-89. doi:10.1111/j.1365-2036.2008.03850.x ISSN 0269-2813.
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Official URL: http://dx.doi.org/10.1111/j.1365-2036.2008.03850.x
Abstract
Background Ghrelin, a potent orexigenic peptide produced by the stomach, may be affected by circulating inflammatory mediators.
Aim To assess the effect of an anti-TNF alpha antibody on ghrelin in patients with Crohn's disease (CD).
Methods Fifteen patients with Crohn's receiving infliximab were studied before and 1 week after infusion. Following an overnight fast, blood was sampled before a meal and then every 20 min for 2 h. Total ghrelin and CRP were measured using ELISA. Acylated ghrelin and TNF alpha, IFN gamma, IL-1 beta and IL-6 were measured with bioplex. Harvey Bradshaw Activity Index was assessed.
Results Median (95% CI) 2-h integrated plasma total ghrelin increased from 162 (99-311) before infliximab to 200 (128-387) pg/mL h, (P = 0.02) after. Following infliximab, 20 min postmeal, median acylated ghrelin decreased from 50.3 (24-64) to 38.6 (26-82) pg/mL, (P = 0.04) thus reverting to a traditional meal related ghrelin curve. Median (range) disease activity decreased from 5 (2-28) before to 3 (0-22), (P = 0.0001) and Median (95% CI) TNFa decreased from 2.8 (1.89-4.48) to 1.31 (0.73-2.06) pg/mL (P = 0.002).
Conclusions Infliximab increases circulating total ghrelin by 25% in CD and restores the postprandial response of acylated ghrelin to food intake. Acylated and de-sacyl ghrelin remain unchanged, suggesting that an alternate isoform could be affected by infliximab.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Crohn's disease -- Treatment -- Research, Ghrelin, Infliximab | ||||
| Journal or Publication Title: | Alimentary Pharmacology and Therapeutic | ||||
| Publisher: | Blackwell Publishing | ||||
| ISSN: | 0269-2813 | ||||
| Official Date: | 1 January 2009 | ||||
| Dates: |
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| Volume: | Vol.29 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 83-89 | ||||
| DOI: | 10.1111/j.1365-2036.2008.03850.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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