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DNA binding and bending by dinuclear complexes comprising ruthenium polypyridyl centres linked by a bis(pyridylimine) ligand
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McDonnell, Ursula, Hicks, Matthew R., Hannon, M. J. (Michael J.) and Rodger, Alison (2008) DNA binding and bending by dinuclear complexes comprising ruthenium polypyridyl centres linked by a bis(pyridylimine) ligand. Journal of Inorganic Biochemistry, Vol.102 (No.12 Sp. Iss. SI). pp. 2052-2059. doi:10.1016/j.jinorgbio.2008.06.006 ISSN 0162-0134.
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Official URL: http://dx.doi.org/10.1016/j.jinorgbio.2008.06.006
Abstract
The interaction of enantiomerically pure dinuclear complexes of the form [Ru-2(L-L)(4)L-1](4+) (where L-L = 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and L-1 = bis(pyridylimine) ligand ((C5H4N)C=N(C6H4))(2)CH2)) with ct-DNA have been investigated by absorbance, circular dichroism, fluorescence displacement assays, thermal analysis, linear dichroism and gel electrophoresis. The complexes all bind more strongly to DNA than ethidium bromide, stabilise DNA and have a significant bending effect on DNA. The data for Delta,Delta-[Ru-2(bpy)(4)L-1](4+) are consistent with it binding to DNA outside the grooves wrapping the DNA about it. By way of contrast the other complexes are groove-binders. The phen complexes provide a chemically and enantiomerically stable alternative to the DNA-coiling di-iron triple-helical cylinder previously studied. In contrast to the di-iron helicates, the phen complexes show DNA sequence effects with Delta,Delta-[Ru-2(phen)(4)L-1](4+) binding preferentially to GC and Lambda,Lambda-[Ru-2(phen)(4)L-1](4+) to AT. (C) 2008 Elsevier Inc. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Ruthenium, Transition metal complexes, Linear dichroism, Ligands (Biochemistry) | ||||
Journal or Publication Title: | Journal of Inorganic Biochemistry | ||||
Publisher: | Elsevier Science Inc | ||||
ISSN: | 0162-0134 | ||||
Official Date: | December 2008 | ||||
Dates: |
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Volume: | Vol.102 | ||||
Number: | No.12 Sp. Iss. SI | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 2052-2059 | ||||
DOI: | 10.1016/j.jinorgbio.2008.06.006 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
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