Ceriello, Antonio, Esposito, Katherine, Piconi, Ludovica, Ihnat, Michael, Thorpe, Jessica, Testa, Roberto, Bonfigli, Anna Rita and Giugliano, Dario. (2008) Glucose "peak" and glucose "spike" : impact on endothelial function and oxidative stress. Diabetes Research and Clinical Practice, Volume 82 (Number 2). pp. 262-267. ISSN 0168-8227

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Abstract

Aim: Data suggest that 2 h hyperglycaemia during an OGTT is less predictive for cardiovascular disease of the glucose "spike" (the difference between the baseline glucose level and the "peak" hyperglycaemia during the test). Methods: A euinsulinemic hyperglycaemic clamp at 10 and 15 mmol/l glucose, with or without vitamin C, was given in increasing steps in diabetic and nor-Mal subjects. Moreover, a hyperglycaemic clamp, 10 mmol/l, was performed in two groups of diabetic patients with different levels of fasting glycaemia. in both the experiments flow mediated dilation and nitrotyrosine were measured. Results: Glucose at 10 and 15 mmol/l resulted in a concentration-dependent induction of endothelial dysfunction and oxidative stress. Vitamin C counterbalanced this effect. The increase of glycaemia to 10 mmol/l induced a significant endothelial dysfunction and increased nitrotyrosine in both the groups of diabetics with different fasting glycaemia. However, when the delta (the difference between the basal value and the peak value) for endothelial function and nitrotyrosine was evaluated, patients with lower basal values showed a worse outcome. Conclusions: Our data suggest that at the same level of hyperglycaemia the grading of the endothelial dysfunction is almost super imposable, but clearly worse in terms of delta from fasting glycaemia. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Glucose, Endothelium, Oxidative stress
Journal or Publication Title:	Diabetes Research and Clinical Practice
Publisher:	Elsevier Ireland Ltd
ISSN:	0168-8227
Date:	November 2008
Volume:	Volume 82
Number:	Number 2
Number of Pages:	6
Page Range:	pp. 262-267
Identification Number:	10.1016/j.diabres.2008.07.015
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
References:	[1] The Diabetes Control and Complications Trial Research Group, The effect of intensive treatment of diabetes on the development and progression of longer complications in insulin-dependent diabetes mellitus, N. Engl. J. Med. 329 (1993) 977–986. [2] UK Prospective Diabetes Study (UKPDS) Group, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes, Lancet 352 (1998) 837–853. [3] C. Stettler, S. Allemann, P. Ju¨ ni, C.A. Cull, R.R. Holman, M. Egger, et al., Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: meta-analysis of randomized trials, Am. Heart J. 152 (2006) 127–138. [4] I.M. Stratton, A.I. Adler, H.A. Neil, D.R. Matthews, S.E. Manley, C.A. Cull, et al., Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study, BMJ 321 (2000) 405–412. [5] K.T. Khaw, N. Wareham, R. Luben, S. Bingham, S. Oakes, A. Welch, et al., Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk), BMJ 322 (2001) 15–18. [6] H.C. Gerstein, et al., The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis, Diabetologia 48 (2005) 1749–1755. [7] P.B. Mellen, V. Bittner, D.M. Herrington, Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women, Diabet. Med. 24 (2007) 1156–1159. [8] The DECODE Study Group, Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria, Lancet 354 (1999) 617–621. [9] B. Balkau, M. Shipley, R.J. Jarrett, K. Pyo¨ ra¨ la¨ , M. Pyo¨ ra¨ la¨, A. Forhan, et al., High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men: 20- year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study, Diabetes Care 21 (1998) 360–367. [10] M. Coutinho, H.C. Gerstein, Y. Wang, S. Yusuf, The relationship between glucose and incident cardiovascular events: a metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years, Diabetes Care 22 (1999) 233–240. [11] A. Ceriello, Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54 (2005) 1–7. [12] T.S. Temelkova-Kurktschiev, C. Koehler, E. Henkel, W. Leonhardt, K. Fuecker, M. Hanefeld, Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level, Diabetes Care 23 (2000) 1830–1834. [13] K. Esposito, M. Ciotola, D. Carleo, B. Schisano, L. Sardelli, D. Di Tommaso, et al., Postmeal glucose peaks at home associate with carotid intima–media thickness in type 2 diabetes, J. Clin. Endocrinol. Metab. 93 (2008) 1345–1350. [14] R.J. Esper, R.A. Nordaby, J.O. Vilarin˜ o, A. Paragano, J.L. Cacharro´ n, R.A. Machado, Endothelial dysfunction: a comprehensive appraisal, Cardiovasc. Diabetol. 5 (2006) 4. [15] A. Ceriello, C. Taboga, L. Tonutti, L. Quagliaro, L. Piconi, B. Bais, et al., Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment, Circulation 106 (2002) 1211–1218. [16] M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature 414 (2001) 813–820. [17] J.A. Beckman, A.B. Goldfine, M.B. Gordon, M.A. Creager, Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans, Circulation 103 (2001) 1618–1623. [18] H.H. Ting, F.K. Timimi, K.S. Boles, S.J. Creager, P. Ganz, M.A. Creager, Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus, J. Clin. Invest. 97 (1996) 22–28. [19] H. Kawano, T. Motoyama, O. Hirashima, N. Hirai, Y. Miyao, T. Sakamoto, et al., Hyperglycemia rapidly suppresses flowmediated endothelium-dependent vasodilation of brachial artery, J. Am. Coll. Cardiol. 34 (1999) 146–154. [20] S. Del Prato, M. Matsuda, D.C. Simonson, L.C. Groop, P. Sheehan, F. Leonetti, et al., Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance, Diabetologia 40 (1997) 687–697. [21] A. Ceriello, S. Kumar, L. Piconi, K. Esposito, D. Giugliano, Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes, Diabetes Care 30 (2007) 649–654. [22] J.M. Graham, J.A. Higgins, T. Gillott, T. Taylor, J. Wilkinson, T. Ford, et al., A novel method for the rapid separation of lipoproteins using self generating gradients of iodixanol, Atherosclerosis 124 (1996) 124–135. [23] A. Ceriello, F. Mercuri, L. Quagliaro, R. Assaloni, E. Motz, L. Tonutti, et al., Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress, Diabetologia 44 (2001) 834–838. [24] M.C. Corretti, G.D. Plotnick, R.A. Vogel, Technical aspects of evaluating brachial artery endothelium-dependent vasodilation using high frequency ultrasound, Am. J. Physiol. 268 (1995) H1397–H1404. [25] M.W. Ramsey, J. Goodfellow, C.J. Jones, L.A. Luddington, M.J. Lewis, A.H. Henderson, Endothelial control of arterial distensibility is impaired in chronic heart failure, Circulation 92 (1995) 3212–3219. [26] C.J. Rodriguez, Y. Miyake, C. Grahame-Clarke, M.R. Di Tullio, R.R. Sciacca, B. Boden-Albala, et al., Relation of plasma glucose and endothelial function in a populationbased multiethnic sample of subjects without diabetes mellitus, Am. J. Cardiol. 96 (2005) 1273–1277. [27] A.B. Goldfine, J.A. Beckman, R.A. Betensky, H. Devlin, S. Hurley, N. Varo, et al., Family history of diabetes is a major determinant of endothelial function, J. Am. Coll. Cardiol. 47 (2006) 2456–2461. [28] A. Ceriello, K. Esposito, L. Piconi, M.A. Ihnat, J.E. Thorpe, R. Testa, et al., Oscillating glucose is more deleterious on endothelial function and oxidative stress than mean glucose in normals and type 2 diabetic patients, Diabetes 57 (2008) 1349–1354. [29] B. Ellger, Y. Debaveye, I. Vanhorebeek, L. Langouche, A. Giulietti, E. Van Etten, et al., Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin, Diabetes 55 (2006) 1096–1105. [30] R. Marfella, L. Quagliaro, F. Nappo, A. Ceriello, D. Giugliano, Acute hyperglycemia induces an oxidative stress in healthy subjects, J. Clin. Invest. 108 (2001) 635–636. [31] S. Pennathur, J.W. Heinecke, Oxidative stress and endothelial dysfunction in vascular disease, Curr. Diab. Rep. 7 (2007) 257–264. [32] S. Pennathur, J.W. Heinecke, Mechanisms for oxidative stress in diabetic cardiovascular disease, Antioxid. Redox Signal 9 (2007) 955–969. [33] M.H. Shishehbor, R.J. Aviles, M.L. Brennan, X. Fu, M. Goormastic, G.L. Pearce, et al., Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy, JAMA 289 (2003) 1675–1680. [34] A. Ceriello, Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction, Eur. Heart J. 26 (2005) 328– 331. [35] P. Deedwania, et al., Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism, Circulation 117 (2008) 1610–1619.
URI:	http://wrap.warwick.ac.uk/id/eprint/28931

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