Conner, Alex C., Kissling, Christian, Hodges, Edward, Huennerkopf, Regina, Clement, R. Marc, Dudley, E. (Edward), Freitag, Christine M., Roesler, Michael, Retz, Wolfgang and Thome, Johannes. (2008) Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , Vol.147B (No.8 ). pp. 1476-1480. ISSN 1552-4841

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Abstract

Adult attention deficit hyperactivity disorder (ADHD) is a widely under-reported but nevertheless common condition with a clear heritable component. Several genes have been proposed to play a role in the childhood onset of this neuro-developmental disorder; however, association studies of persistence of ADHD into adulthood have rarely been per-formed. Neurotrophic factors (NTFs) are known to be involved in several aspects of neuronal development and neural plasticity in adults. They have also been linked, particularly through brain-derived neurotrophic factor (BDNF) interaction with dopamine transport, to the pathophysiology of ADHD. This study compares the genotypes of six different single nucleotide polymorphisms of genes within the neurotrophin system and their possible association with adult ADHD score in 143 high-risk male subjects referred to a forensic psychiatric unit. The genes included NTF3 NTRK2 (TrkB), NTRK3 (TrkC), BDNF, and p75(NTR). While none of the SNPs showed significant association with ADHD symptoms, one polymorphism within the exon of NTF3 (rs6332) showed a trend toward an association between the A-allele and increased scores using both the retrospective childhood analysis Wender-Utah Rating Scale (WURS-k) (P=0.05) and the adult ADHD assessment Wender-Reimherr interview (P = 0.03). This SNP is a silent mutation which might be in linkage disequilibrium with a functional risk variant for ADHD. As the association was only suggestive, however, this finding needs replication in a larger study with higher power. (c) 2008 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Attention-deficit disorder in adults, Neurotrophic functions, Chromosome polymorphism, Human genetics -- Variation, Genetic markers, Genetic epidemiology
Journal or Publication Title:	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Publisher:	John Wiley & Sons, Inc.
ISSN:	1552-4841
Date:	5 December 2008
Volume:	Vol.147B
Number:	No.8
Number of Pages:	5
Page Range:	pp. 1476-1480
Identification Number:	10.1002/ajmg.b.30632
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Deutsche Forschungsgemeinschaft (DFG)
Grant number:	DFG HU1536/1-1 (DFG)
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URI:	http://wrap.warwick.ac.uk/id/eprint/28953

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