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Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population

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Conner, Alex C., Kissling, Christian, Hodges, Edward, Huennerkopf, Regina, Clement, R. Marc, Dudley, E. (Edward), Freitag, Christine M., Roesler, Michael, Retz, Wolfgang and Thome, Johannes. (2008) Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , Vol.147B (No.8 ). pp. 1476-1480. ISSN 1552-4841

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Official URL: http://dx.doi.org/10.1002/ajmg.b.30632

Abstract

Adult attention deficit hyperactivity disorder (ADHD) is a widely under-reported but nevertheless common condition with a clear heritable component. Several genes have been proposed to play a role in the childhood onset of this neuro-developmental disorder; however, association studies of persistence of ADHD into adulthood have rarely been per-formed. Neurotrophic factors (NTFs) are known to be involved in several aspects of neuronal development and neural plasticity in adults. They have also been linked, particularly through brain-derived neurotrophic factor (BDNF) interaction with dopamine transport, to the pathophysiology of ADHD. This study compares the genotypes of six different single nucleotide polymorphisms of genes within the neurotrophin system and their possible association with adult ADHD score in 143 high-risk male subjects referred to a forensic psychiatric unit. The genes included NTF3 NTRK2 (TrkB), NTRK3 (TrkC), BDNF, and p75(NTR). While none of the SNPs showed significant association with ADHD symptoms, one polymorphism within the exon of NTF3 (rs6332) showed a trend toward an association between the A-allele and increased scores using both the retrospective childhood analysis Wender-Utah Rating Scale (WURS-k) (P=0.05) and the adult ADHD assessment Wender-Reimherr interview (P = 0.03). This SNP is a silent mutation which might be in linkage disequilibrium with a functional risk variant for ADHD. As the association was only suggestive, however, this finding needs replication in a larger study with higher power. (c) 2008 Wiley-Liss, Inc.

Item Type:

Journal Article

Subjects:

Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

Divisions:

Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School

Library of Congress Subject Headings (LCSH):

Attention-deficit disorder in adults, Neurotrophic functions, Chromosome polymorphism, Human genetics -- Variation, Genetic markers, Genetic epidemiology

Journal or Publication Title:

American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

Publisher:

John Wiley & Sons, Inc.

ISSN:

1552-4841

Official Date:

5 December 2008

Dates:

Date	Event
5 December 2008	Published

Volume:

Vol.147B

Number:

No.8

Number of Pages:

Page Range:

pp. 1476-1480

Identification Number:

10.1002/ajmg.b.30632

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Deutsche Forschungsgemeinschaft (DFG)

Grant number:

DFG HU1536/1-1 (DFG)

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