Stochastic niche structure and diversity maintenance in the T cell repertoire
Stirk, Emily R., Molina-Paris, Carmen and Berg, Hugo van den. (2008) Stochastic niche structure and diversity maintenance in the T cell repertoire. Journal of Theoretical Biology, Vol.255 (No.2). pp. 237-249. ISSN 0022-5193Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.jtbi.2008.07.017
The reliability of the immune response to pathogenic challenge depends critically on the size and diversity of the T cell repertoire. We study naive T cell repertoire diversity maintenance by a stochastic model that incorporates the concept of competition between T cells for survival stimuli emanating from self-antigen presenting cells (APCs). in the mean field approximation we show that clonotype extinction is certain and compute mean extinction times. We introduce the concept of mean niche overlap and show that clones with a mean niche overlap greater than one have a short repertoire lifespan. This selection differential induces minimal recognition commonality between T cell receptors (TCRs) resulting in a diverse T cell repertoire. (C) 2008 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculty of Science > Mathematics|
|Library of Congress Subject Headings (LCSH):||Lymphocyte transformation, Markov processes, Birth and death processes (Stochastic processes), Distribution (Probability theory), T cells|
|Journal or Publication Title:||Journal of Theoretical Biology|
|Official Date:||21 November 2008|
|Number of Pages:||13|
|Page Range:||pp. 237-249|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), University of Leeds|
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