Peacock, Anna F. A. and Sadler, P. J. (2008) Medicinal organometallic chemistry : designing metal arene complexes as anticancer agents. Chemistry - An Asian Journal, Vol.3 (No.11). pp. 1890-1899. ISSN 1861-4728

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Abstract

The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organometallic compounds -- Therapeutic use, Arene compounds -- Therapeutic use, Ruthenium, Osmium
Journal or Publication Title:	Chemistry - An Asian Journal
Publisher:	Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:	1861-4728
Date:	13 November 2008
Volume:	Vol.3
Number:	No.11
Number of Pages:	10
Page Range:	pp. 1890-1899
Identification Number:	10.1002/asia.200800149
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/29031

Data sourced from Thomson Reuters' Web of Knowledge

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