Medicinal organometallic chemistry : designing metal arene complexes as anticancer agents
Peacock, Anna F. A. and Sadler, P. J. (2008) Medicinal organometallic chemistry : designing metal arene complexes as anticancer agents. Chemistry - An Asian Journal, Vol.3 (No.11). pp. 1890-1899. ISSN 1861-4728Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/asia.200800149
The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.
|Item Type:||Journal Item|
|Subjects:||Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Organometallic compounds -- Therapeutic use, Arene compounds -- Therapeutic use, Ruthenium, Osmium|
|Journal or Publication Title:||Chemistry - An Asian Journal|
|Publisher:||Wiley - V C H Verlag GmbH & Co. KGaA|
|Official Date:||13 November 2008|
|Number of Pages:||10|
|Page Range:||pp. 1890-1899|
|Access rights to Published version:||Restricted or Subscription Access|
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