Aitkenhead, Adam H., Mills, John A. and Wilson, Adrian J.. (2008) The design and characterization of an ultrasound phased array suitable for deep tissue hyperthermia. Ultrasound in Medicine & Biology, Volume 34 (Number 11). pp. 1793-1807. ISSN 0301-5629

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Abstract

In this paper we describe the design and evaluation of a planar phased-array ultrasound transducer suitable for producing localized hyperthermia in solid tumors deep within the body. Simulation using a customized version of Ultrasim has been used to determine the relationship between the size and position of the focus and parameters of the array. These parameters include the overall size of the array and the size, shape and distribution of the individual elements. A 15-element prototype array has been constructed using the results of the simulation. Beam profile measurements on this transducer made in an acoustic tank were compared with the beam profile predicted by simulation. The results showed good agreement in the shape of the focal region, but with the focus closer to the surface of the physical transducer when compared with the simulation and with small high-intensity areas between the surface of the transducer and the focus in the measured profile. A sensitivity analysis using a simulated factorial experiment indicated that the presence of a secondary vibrational mode within the elements of the array was the principal cause for both the shift in the position of the focus and for the unwanted maxima close to the surface of the array. The results also showed that the array was tolerant of a large variation in output intensity of the individual elements in the array in producing a focal region. Extrapolation of the results obtained in this study indicate that an array of 60 elements, based on the design described, driven by 550 V peak-to-peak pulses would be capable of producing a peak focal intensity of 50 Wcm(-2) at a depth of 60 mm in tissue, which would be appropriate for hyperthermia used as an adjunct to radiotherapy or chemotherapy. (E-mail: a.h.aitkenhead@warwick.ac.uk) (C) 2008 World Federation for Ultrasound in Medicine & Biology.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:	Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	Ultrasonics in medicine, Fever, Phased array antennas
Journal or Publication Title:	Ultrasound in Medicine & Biology
Publisher:	Elsevier Inc.
ISSN:	0301-5629
Date:	November 2008
Volume:	Volume 34
Number:	Number 11
Number of Pages:	15
Page Range:	pp. 1793-1807
Identification Number:	10.1016/j.ultrasmedbio.2008.04.001
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/29042

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