Ceriello, Antonio (2008) Postprandial hyperglycaemia : a new risk factor for cardiovascular disease. Diabetes, Stoffwechsel und Herz, Vol.17 (No.5). pp. 363-373. ISSN 1861-7603

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Abstract

Type 2 diabetes is primarily a disorder of post-prandial glucose regulation, characterized by a gradual decline in insulin secretion in response to nutrient loads. Despite this, physicians continue to rely on fasting blood glucose and glycosylated haemoglobin (HbA(1c)) to guide management. There is a linear relationship between the risk of cardiovascular death and the 2-hour oral glucose tolerance test (OGTT). A recent study demonstrated that postprandial hyperglycaemia is an independent risk factor for cardiovascular disease in type 2 diabetes. Also, several intervention studies have shown that treating postprandial hyoerglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that post-prandial hyperglycaemia may lead to cardiovascular disease through the generation of oxidative stress. Furthermore, clinical data suggest that post-prandial hyperglycaemia is a common phenomenon, even in patients who may be considered as having good metabolic control.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Hyperglycemia, Cardiovascular system -- Diseases -- Risk factors, Non-insulin-dependent diabetes
Journal or Publication Title:	Diabetes, Stoffwechsel und Herz
Publisher:	Verlag Kirchheim und Co. GmbH
ISSN:	1861-7603
Date:	20 September 2008
Volume:	Vol.17
Number:	No.5
Number of Pages:	11
Page Range:	pp. 363-373
Status:	Not Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/29092

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