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Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase
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Gallienne, Estelle, Muccioli, Giulio G., Lambert, Didier M. and Shipman, Michael (2008) Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase. Tetrahedron Letters, Volume 49 (Number 46). pp. 6495-6497. doi:10.1016/j.tetlet.2008.08.100 ISSN 0040-4039.
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.08.100
Abstract
Monothiohydantoin 3a is made in seven steps front 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC50) = 23.4 +/- 1.1 mu M). The key step in the sequence involves a microwave-assisted four- component reaction that makes the 5,5'-disubstituted hydantoin nucleus by the sequential formation of two C-C and two C-N bonds. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Fatty acids, Amides, Hydantoin, Chemical reactions, Microwaves, Hydrolases -- Inhibitors | ||||
| Journal or Publication Title: | Tetrahedron Letters | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0040-4039 | ||||
| Official Date: | 10 November 2008 | ||||
| Dates: |
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| Volume: | Volume 49 | ||||
| Number: | Number 46 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 6495-6497 | ||||
| DOI: | 10.1016/j.tetlet.2008.08.100 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Fonds national de la recherche scientifique (Belgium) (FNRS) | ||||
| Grant number: | EP/E501184/1 (EPSRC) |
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