Gallienne, Estelle, Muccioli, Giulio G., Lambert, Didier M. and Shipman, Michael. (2008) Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase. Tetrahedron Letters, Volume 49 (Number 46). pp. 6495-6497. ISSN 0040-4039

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Abstract

Monothiohydantoin 3a is made in seven steps front 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC50) = 23.4 +/- 1.1 mu M). The key step in the sequence involves a microwave-assisted four- component reaction that makes the 5,5'-disubstituted hydantoin nucleus by the sequential formation of two C-C and two C-N bonds. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Fatty acids, Amides, Hydantoin, Chemical reactions, Microwaves, Hydrolases -- Inhibitors
Journal or Publication Title:	Tetrahedron Letters
Publisher:	Pergamon
ISSN:	0040-4039
Date:	10 November 2008
Volume:	Volume 49
Number:	Number 46
Number of Pages:	3
Page Range:	pp. 6495-6497
Identification Number:	10.1016/j.tetlet.2008.08.100
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Fonds national de la recherche scientifique (Belgium) (FNRS)
Grant number:	EP/E501184/1 (EPSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/29112

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