Shi, Yan, Gu, Mei, Fan, Zaifeng and Hong, Yiguo (2008) RNA silencing suppressors : how viruses fight back. Future Virology, Volume 3 (Number 2). pp. 125-133. doi:10.2217/17460794.3.2.125

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Abstract

RNA silencing is a collective term that refers to diverse RNA-directed processes resulting in sequence-specific degradation of target RNA and repression of gene expression, either at transcriptional or post-transcriptional levels. In animals, fungi and plants, RNA silencing represents a mechanism guided by small RNAs against virus infection. Viruses can be inducers and targets of RNA silencing, and have evolved active and passive strategies to counter the cellular antiviral mechanism. This review discusses various approaches, including protein- and RNA-mediated silencing suppression and viral escape of RNA silencing without suppression, to highlight how viruses could fight back to survive under the universal host surveillance.

Item Type:	Journal Item
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)
Library of Congress Subject Headings (LCSH):	Gene silencing, RNA, Viral genetics
Journal or Publication Title:	Future Virology
Publisher:	Future Medicine Ltd.
ISSN:	1746-0794
Official Date:	March 2008
Dates:	Date Event March 2008 Published
Volume:	Volume 3
Number:	Number 2
Number of Pages:	9
Page Range:	pp. 125-133
DOI:	10.2217/17460794.3.2.125
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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