Duration of shedding of respiratory syncytial virus in a community study of Kenyan children
Okiro, E. A., White, L. J., Ngama, Mwanajuma, Cane, Patricia, Medley, Graham and Nokes, D. James. (2010) Duration of shedding of respiratory syncytial virus in a community study of Kenyan children. BMC Infectious Diseases, Vol.10 (Article 15). ISSN 1471-2334
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Official URL: http://dx.doi.org/10.1186/1471-2334-10-15
Background: Our understanding of the transmission dynamics of respiratory syncytial virus (RSV) infection will be better informed with improved data on the patterns of shedding in cases not limited only to hospital admissions.
Methods: In a household study, children testing RSV positive by direct immunofluorescent antibody test (DFA) were enrolled. Nasal washings were scheduled right away, then every three days until day 14, every 7 days until day 28 and every 2 weeks until a maximum of 16 weeks, or until the first DFA negative RSV specimen. The relationship between host factors, illness severity and viral shedding was investigated using Cox regression methods.
Results: From 151 families a total of 193 children were enrolled with a median age of 21 months (range 1-164 months), 10% infants and 46% male. The rate of recovery from infection was 0.22/person/day (95% CI 0.19-0.25) equivalent to a mean duration of shedding of 4.5 days (95%CI 4.0-5.3), with a median duration of shedding of 4 days (IQR 2-6, range 1-14). Children with a history of RSV infection had a 40% increased rate of recovery i.e. shorter duration of viral shedding (hazard ratio 1.4, 95% CI 1.01-1.86). The rate of cessation of shedding did not differ significantly between males and females, by severity of infection or by age.
Conclusion: We provide evidence of a relationship between the duration of shedding and history of infection, which may have a bearing on the relative role of primary versus re-infections in RSV transmission in the community.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RJ Pediatrics|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Respiratory syncytial virus -- Kenya, Fluorescent antibody technique, Immunofluorescence, Virus diseases in children -- Kenya|
|Journal or Publication Title:||BMC Infectious Diseases|
|Publisher:||BioMed Central Ltd.|
|Official Date:||22 January 2010|
|Access rights to Published version:||Open Access|
|Funder:||Wellcome Trust (London, England)|
|Grant number:||061584 (Wellcome), 076278 (Wellcome)|
1. Simoes EA: Respiratory syncytial virus infection. Lancet 1999,
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