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Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry
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Ronconi, Luca and Sadler, P. J. (2008) Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews, Vol.252 (No.21-22). pp. 2239-2277. ISSN 0010-8545
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Official URL: http://dx.doi.org/10.1016/j.ccr.2008.01.016
Abstract
There is a wide range of potential applications of inorganic compounds, and metal coordination complexes in particular, in medicine but progress is hampered by a lack of methods to study their speciation. The biological activity of metal complexes is determined by the metal itself, its oxidation state, the types and number of coordinated ligands and their strength of binding, the geometry of the complex, redox potential and ligand exchange rates. For organic drugs a variety of readily observed spin I = 1/2 nuclei can be used (H-1, C-13, N-15, F-19, P-31), but only a few metals fall into this category. Most are quadrupolar nuclei giving rise to broad lines with low detection sensitivity (for biological systems). However we show that, in some cases, heteronuclear NMR studies can provide new insights into the biological and medicinal chemistry of a range of elements and these data will stimulate further advances in this area. (C) 2008 Elsevier B.V. All rights reserved.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Nuclear magnetic resonance spectroscopy, Nuclear quadrupole resonance spectroscopy, Biological systems, Bioinorganic chemistry, Organometallic compounds -- Therapeutic use |
| Journal or Publication Title: | Coordination Chemistry Reviews |
| Publisher: | Elsevier BV |
| ISSN: | 0010-8545 |
| Date: | November 2008 |
| Volume: | Vol.252 |
| Number: | No.21-22 |
| Number of Pages: | 39 |
| Page Range: | pp. 2239-2277 |
| Identification Number: | 10.1016/j.ccr.2008.01.016 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Seventh Framework Programme (European Commission) (FP7), Körber-Stiftung |
| URI: | http://wrap.warwick.ac.uk/id/eprint/29231 |
Data sourced from Thomson Reuters' Web of Knowledge
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