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Advances in PEGylation of important biotech molecules : delivery aspects
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Ryan, Sinead M., Mantovani, Giuseppe, Wang, Xuexuan, Haddleton, David M. and Brayden, David J. (2008) Advances in PEGylation of important biotech molecules : delivery aspects. Expert Opinion on Drug Delivery, Vol.5 (No.4). pp. 371-383. ISSN 1742-5247
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Official URL: http://dx.doi.org/10.1517/17425247.5.4.371
Abstract
Background: Although various injected peptide and protein therapeutics have been developed successfully over the past 25 years, several pharmacokinetic and immunological challenges are still encountered that can limit the efficacy of both novel and established biotech molecules. Objective and method: PEGylation is a popular technique to address such properties. PEGylated drugs exhibit prolonged half-life, higher stability, water solubility, lower immunogenicity and antigenicity, as well as potential for specific cell targeting. Although PEGylated drug conjugates have been on the market for many years, the technology has steadily developed in respect of site-specific chemistry, chain length, molecular weights and purity of conjugate. These developments have occurred in parallel to improvements in physicochemical methods of characterization. Conclusion: This review will discuss recent achievements in PEGylation processes with an emphasis on novel PEG-drugs constructs, the unrealized potential of PEGylation for non-injected routes of delivery, and also on PEGylated versions of polymeric nanoparticles, including dendrimers and liposomes.
| Item Type: | Journal Item |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Drug delivery systems, Molecular biotechnology, Dendrimers in medicine, Liposomes |
| Journal or Publication Title: | Expert Opinion on Drug Delivery |
| Publisher: | Informa Healthcare |
| ISSN: | 1742-5247 |
| Date: | April 2008 |
| Volume: | Vol.5 |
| Number: | No.4 |
| Number of Pages: | 13 |
| Page Range: | pp. 371-383 |
| Identification Number: | 10.1517/17425247.5.4.371 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Science Foundation Ireland (SFI), Warwick Effect Polymers Ltd |
| Grant number: | 04 IN3 B575 (SFI) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/29252 |
Data sourced from Thomson Reuters' Web of Knowledge
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