Ryan, Sinead M., Mantovani, Giuseppe, Wang, Xuexuan, Haddleton, David M. and Brayden, David J. (2008) Advances in PEGylation of important biotech molecules : delivery aspects. Expert Opinion on Drug Delivery, Vol.5 (No.4). pp. 371-383. ISSN 1742-5247

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Abstract

Background: Although various injected peptide and protein therapeutics have been developed successfully over the past 25 years, several pharmacokinetic and immunological challenges are still encountered that can limit the efficacy of both novel and established biotech molecules. Objective and method: PEGylation is a popular technique to address such properties. PEGylated drugs exhibit prolonged half-life, higher stability, water solubility, lower immunogenicity and antigenicity, as well as potential for specific cell targeting. Although PEGylated drug conjugates have been on the market for many years, the technology has steadily developed in respect of site-specific chemistry, chain length, molecular weights and purity of conjugate. These developments have occurred in parallel to improvements in physicochemical methods of characterization. Conclusion: This review will discuss recent achievements in PEGylation processes with an emphasis on novel PEG-drugs constructs, the unrealized potential of PEGylation for non-injected routes of delivery, and also on PEGylated versions of polymeric nanoparticles, including dendrimers and liposomes.

Item Type:	Journal Item
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Drug delivery systems, Molecular biotechnology, Dendrimers in medicine, Liposomes
Journal or Publication Title:	Expert Opinion on Drug Delivery
Publisher:	Informa Healthcare
ISSN:	1742-5247
Official Date:	April 2008
Volume:	Vol.5
Number:	No.4
Number of Pages:	13
Page Range:	pp. 371-383
Identification Number:	10.1517/17425247.5.4.371
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Science Foundation Ireland (SFI), Warwick Effect Polymers Ltd
Grant number:	04 IN3 B575 (SFI)
URI:	http://wrap.warwick.ac.uk/id/eprint/29252

Data sourced from Thomson Reuters' Web of Knowledge

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