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Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys
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Nigatu, Wondatir, Samuel, Dhan, Cohen, Bernard, Cumberland, Phillippa, Lemma, Eshetu, Brown, David W. G. and Nokes, D. James (2008) Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys. Vaccine, Vol.26 (No.37). pp. 4769-4774. doi:10.1016/j.vaccine.2008.07.005
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Official URL: http://dx.doi.org/10.1016/j.vaccine.2008.07.005
Abstract
We undertook a study to demonstrate the potential contribution of oral-fluid (OF) antibody prevalence surveys in evaluating measles vaccine campaigns. In Asela town, southern Ethiopia, oral fluids were collected from 1928 children aged 9 months to 5 years attending for campaign immunization in December 1999 and 6 months later, from 745 individuals aged 9 months to 19 years, in the same location. Measles antibody status was determined by microimmune measles specific IgG enzyme immunoassay (EIA). Antibody prevalence was estimated at 48% in children attending for vaccination (pre-campaign), and 85% post-campaign in the comparable age group. The estimated reduction in the susceptible proportion was 75%. In older children the proportion antibody negative post-campaign was 28% in 7-9 year olds, and 13% in 10-14 year olds levels of susceptibility which raise concern over continued measles transmission. This is the first evaluation of a measles vaccine campaign based on oral-fluid seroprevalence surveys and it demonstrates the merit of oral-fluid surveys in informing health authorities about vaccination strategy refinement. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Library of Congress Subject Headings (LCSH): | Measles -- Vaccination -- Ethiopia -- Evaluation | ||||
| Journal or Publication Title: | Vaccine | ||||
| Publisher: | Elsevier Ltd. | ||||
| ISSN: | 0264-410X | ||||
| Official Date: | 2 September 2008 | ||||
| Dates: |
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| Volume: | Vol.26 | ||||
| Number: | No.37 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 4769-4774 | ||||
| DOI: | 10.1016/j.vaccine.2008.07.005 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | World Health Organization. Department of Vaccines and Biologicals, BASICS, USA, British Council (Ethiopia) | ||||
| Grant number: | V21/181/133 (WHO) |
Data sourced from Thomson Reuters' Web of Knowledge
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