Nigatu, Wondatir, Samuel, Dhan, Cohen, Bernard, Cumberland, Phillippa, Lemma, Eshetu, Brown, David W. G. and Nokes, D. James (2008) Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys. Vaccine, Vol.26 (No.37). pp. 4769-4774. ISSN 0264-410X

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Abstract

We undertook a study to demonstrate the potential contribution of oral-fluid (OF) antibody prevalence surveys in evaluating measles vaccine campaigns. In Asela town, southern Ethiopia, oral fluids were collected from 1928 children aged 9 months to 5 years attending for campaign immunization in December 1999 and 6 months later, from 745 individuals aged 9 months to 19 years, in the same location. Measles antibody status was determined by microimmune measles specific IgG enzyme immunoassay (EIA). Antibody prevalence was estimated at 48% in children attending for vaccination (pre-campaign), and 85% post-campaign in the comparable age group. The estimated reduction in the susceptible proportion was 75%. In older children the proportion antibody negative post-campaign was 28% in 7-9 year olds, and 13% in 10-14 year olds levels of susceptibility which raise concern over continued measles transmission. This is the first evaluation of a measles vaccine campaign based on oral-fluid seroprevalence surveys and it demonstrates the merit of oral-fluid surveys in informing health authorities about vaccination strategy refinement. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type:	Journal Item
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Measles -- Vaccination -- Ethiopia -- Evaluation
Journal or Publication Title:	Vaccine
Publisher:	Elsevier Ltd.
ISSN:	0264-410X
Date:	2 September 2008
Volume:	Vol.26
Number:	No.37
Number of Pages:	6
Page Range:	pp. 4769-4774
Identification Number:	10.1016/j.vaccine.2008.07.005
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	World Health Organization. Department of Vaccines and Biologicals, BASICS, USA, British Council (Ethiopia)
Grant number:	V21/181/133 (WHO)
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URI:	http://wrap.warwick.ac.uk/id/eprint/29279

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