Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort
Zammit, Stanley, Horwood, Jeremy, Thompson, Andrew, 1932-, Thomas, Kate, 1972-, Menezes, Paulo, Gunnel, David, Hollis, Chris, Wolke, Dieter, Lewis, Glyn and Harrison, Glynn. (2008) Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort. Schizophrenia Research, Vol.104 (No.1-3). pp. 279-286. ISSN 0920-9964Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.schres.2008.04.036
Psychosis-like symptoms (PLIKS) occur in about 15% of the Population, but it is unclear to what extent PLIKS share aetiological mechanisms in common with those for schizophrenia. We examined whether the presence of PLIKS was associated with a family history of schizophrenia (FH-SCZ), or with advancing paternal age, using data from 6356 children in the ALSPAC birth cohort who participated in a semi-structured PLIKS interview at 12 years of age. We found no evidence of association between FH-SCZ and suspected or definite PLIKS (adjusted OR=0.94, 95%CI 0.44, 2.00; p=0.880). There was weak evidence that advancing paternal age vas associated with increased PLIKS (adjusted OR per 10-year age increase = 1.23, 95%CI 0.99, 1.55; p=0.058). Although not a priori hypotheses, family history of depression (adjusted OR = 1.28, 95%CI 1.04, 1.57; p=0.018), and younger maternal age (adjusted OR per 10-year age increase = 0.62, 95% CI 0.47, 0.82; p<0.001) both showed stronger evidence of association with suspected or definite PLIKS. Overall our findings provide little evidence that these established risk factors for schizophrenia show a similar relationship with PLIKS, suggesting that the presence of PLIKS is unlikely to be a strong marker of early expression of the pathology underlying schizophrenia. Whether future studies of PLIKS will increase our understanding of mechanisms underlying the development of schizophrenia, or prove useful in prediction of this disorder, remains to be seen. (C) 2008 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Science > Psychology
|Library of Congress Subject Headings (LCSH):||Schizophrenia, Psychoses, Schizophrenia -- Genetic aspects, Schizophrenia -- Longitudinal studies, Cohort analysis|
|Journal or Publication Title:||Schizophrenia Research|
|Number of Pages:||8|
|Page Range:||pp. 279-286|
|References:||Callaway, L.K., McIntyre, H.D., O'Callaghan, M., Williams, G.M., Najman, J.M., Lawlor, D.A., 2007. The association of hypertensive disorders of pregnancy with weight gain over the subsequent 21 years: findings from a prospective cohort study. Am. J. Epidemiol. 166, 421–428. Cardno, A.G.,Marshall, E.J.,Coid, B.,Macdonald,A.M., Ribchester, T.R., Davies, N.J., Venturi, P., Jones, L.A., Lewis, S.W., Sham, P.C., Gottesman, I.I., Farmer, A.E., McGuffin, P., Reveley, A.M., Murray, R.M., 1999. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch. Gen. Psychiatry 56, 162–168. Crow, J.F., 1997. The high spontaneous mutation rate: is it a health risk? Proc. Natl. Acad. Sci. U.S.A. 94, 8380–8386. Eaton, W.W., Romanoski, A., Anthony, J.C., Nestadt, G., 1991. Screening for psychosis in the general population with a self-report interview. J. Nerv. Ment. Dis. 179, 689–693. Golding, J., Pembrey, M., Jones, R., 2001. ALSPAC—the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr. Perinat. Epidemiol. 15, 74–87. Hanssen, M., Bak, M., Bijl, R., Vollebergh, W., van Os, J., 2005. The incidence and outcome of subclinical psychotic experiences in the general population. Br. J. Clin. Psychol. 44, 181–191. Hay, D.A., Martin, N.G., Foley, D., Treloar, S.A., Kirk, K.M., Heath, A.C., 2001. Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study. Twin Res. 4, 30–40. Horwood, J., Thomas, K., Duffy, L., Gunnell, D., Hollis, C., Lewis, G., Thompson, A., Wolke, D., Zammit, S., Harrison, G., 2008. Frequency of psychosis-like symptoms in a non-clinical population of 12 year olds: results from the Alspac Birth Cohort. Schizophr. Res. 98, 77–78. Johns, L.C., Cannon, M., Singleton, N., Murray, R.M., Farrell, M., Brugha, T., Bebbington, P., Jenkins, R., Meltzer, H., 2004. Prevalence and correlates of self-reported psychotic symptoms in the British population. Br. J. Psychiatry 185, 298–305. Kendler, K.S., Gallagher, T.J., Abelson, J.M., Kessler, R.C., 1996. Lifetime prevalence, demographic risk factors, and diagnostic validity of nonaffective psychosis as assessed in a US community sample. The National Comorbidity Survey. Arch. Gen. Psychiatry 53, 1022–1031. Laurens, K.R., Hodgins, S., Maughan, B., Murray, R.M., Rutter, M.L., Taylor, E.A., 2007. Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9–12 years. Schizophr. Res. 90, 130–146. Linney, Y.M., Murray, R.M., Peters, E.R., MacDonald, A.M., Rijsdijk, F., Sham, P.C., 2003. A quantitative genetic analysis of schizotypal personality traits. Psychol. Med. 33, 803–816. Malaspina, D., Harlap, S., Fennig, S., Heiman, D., Nahon, D., Feldman, D., Susser, E.S., 2001. Advancing paternal age and the risk of schizophrenia. Arch. Gen. Psychiatry 58, 361–367. Pedersen, C.B., Mortensen, P.B., 2001. Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis. Br. J. Psychiatry 179, 46–52. Perala, J., Suvisaari, J., Saarni, S.I., Kuoppasalmi, K., Isometsa, E., Pirkola, S., Partonen, T., Tuulio-Henriksson, A., Hintikka, J., Kieseppa, T., Harkanen, T., Koskinen, S., Lonnqvist, J., 2007. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch. Gen. Psychiatry 64, 19–28. Peters, E.R., Joseph, S.A., Garety, P.A., 1999. Measurement of delusional ideation in the normal population: introducing the PDI (Peters et al. Delusions Inventory). Schizophr. Bull. 25, 553–576. Plewis, I., Calderwoof, L., Hawkes, D., Nathan, G., 2004. National Child Development Study and 1970 British Cohort Study Technical Report:Changes in the NCDS and BCS70 populations and samples over time. Institute of Education, London: Centre for Longitudinal Studies. Poulton, R., Caspi, A., Moffitt, T.E., Cannon, M., Murray, R., Harrington, H., 2000. Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch. Gen. Psychiatry 57, 1053–1058. Raghunathan, T.E., Lepkowski, J.M., Van Hoewyk, J., Solenberger, P., 2001. A multivariate technique for multiply imputing missing values using a sequence of regression models. Sur. Methodol. 27, 85–95. Royston, P., 2004. Multiple imputation of missing values. Stata Journal 3, 227–241. Shaffer, D., Fisher, P., Lucas, C.P., Dulcan, M.K., Schwab-Stone, M.E., 2000. NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J. Am. Acad. Child Adolesc. Psych. 39, 28–38. Sipos, A., Rasmussen, F., Harrison, G., Tynelius, P., Lewis, G., Leon, D.A., Gunnell, D., 2004. Paternal age and schizophrenia: a population based cohort study. BMJ 329, 1070. Trautmann-Villalba, P., Gerhold, M., Laucht, M., Schmidt, M.H., 2004. Early motherhood and disruptive behaviour in the schoolage child. Acta. Paediatr. 93, 120–125. van Os, J., Hanssen, M., Bijl, R.V., Vollebergh, W., 2001. Prevalence of psychotic disorder and community level of psychotic symptoms: an urban–rural comparison. Arch. Gen. Psychiatry 58, 663–668. Verdoux, H., Maurice-Tison, S., Gay, B., Van Os, J., Salamon, R., Bourgeois, M.L., 1998. A survey of delusional ideation in primarycare patients. Psychol. Med. 28, 127–134. Wechsler, D., 1991. Manual for theWechsler Intelligence Scale for Children—Third Edition (WISC-III). Psychological Corporation, San Antonio, TX. WHO, 1994. Schedules for Clinical Assessment Inneuropsychiatry. American Psychiatric Research, Washington, DC. Wiles, N.J., Zammit, S., Bebbington, P., Singleton, N., Meltzer, H., Lewis, G., 2006. Self-reported psychotic symptoms in the general population: results from the longitudinal study of the British National Psychiatric Morbidity Survey. Br. J. Psychiatry 188, 519–526. Zammit, S., Allebeck, P., Dalman, C., Lundberg, I., Hemmingson, T., Owen, M.J., Lewis, G., 2003. Paternal age and risk for schizophrenia. Br. J. Psychiatry 183, 405–408.|
Actions (login required)