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Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative

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Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S. and Challis, Gregory L.. (2008) Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative. Chemical Communications (No.34). pp. 4034-4036. ISSN 1359-7345

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Official URL: http://dx.doi.org/10.1039/b809353a

Abstract

The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N-1-(3,4-dihydroxbenzoyl)-spermidine, with N-8-citryl-spermidine or N-1-(3,4-dihydroxbenzoyl)-N-8-citryl-spermidine, suggesting that N-1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Siderophores -- Synthesis, Siderophores -- Therapeutic use, Spermidine

Journal or Publication Title:

Chemical Communications

Publisher:

Royal Society of Chemistry

ISSN:

1359-7345

Official Date:

14 September 2008

Dates:

Date	Event
14 September 2008	Published

Number:

No.34

Number of Pages:

Page Range:

pp. 4034-4036

Identification Number:

10.1039/b809353a

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)

Grant number:

BB/FO13760/1 (BBSRC)

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