The Library

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative

Tools

Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S. and Challis, Gregory L.. (2008) Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative. Chemical Communications (No.34). pp. 4034-4036. ISSN 1359-7345

Full text not available from this repository.

Abstract

The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N-1-(3,4-dihydroxbenzoyl)-spermidine, with N-8-citryl-spermidine or N-1-(3,4-dihydroxbenzoyl)-N-8-citryl-spermidine, suggesting that N-1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Siderophores -- Synthesis, Siderophores -- Therapeutic use, Spermidine
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 14 September 2008
Number: No.34
Number of Pages: 3
Page Range: pp. 4034-4036
Identification Number: 10.1039/b809353a
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/FO13760/1 (BBSRC)
References:

1 U. E. Schaible and S. H. E. Kaufmann, Nat. Rev. Microbiol., 2004,
2, 946–953.
2 J. H. Crosa and C. T. Walsh, Microbiol. Mol. Biol. Rev., 2002, 66,
223–249.
3 G. L. Challis, ChemBioChem, 2005, 6, 601–611.
4 F. Barona-Gomez, U. Wong, A. Giannakopulos, P. J. Derrick and
G. L. Challis, J. Am. Chem. Soc., 2004, 126, 16282–16283.
5 D. Oves-Costales, N. Kadi, M. J. Fogg, L. Song, K. S. Wilson and
G. L. Challis, J. Am. Chem. Soc., 2007, 129, 8416–8417.
6 N. Kadi, D. Oves-Costales, F. Barona-Gomez and G. L. Challis,
Nat. Chem. Biol., 2007, 3, 652–656.
7 (a) M. Marcus and M. A. Marahiel, Microbiol. Mol. Biol. Rev.,
2007, 71, 413–451; (b) R. R.Monfeli and C. Beeson, Infect. Disord.
Drug Targets, 2007, 7, 213–220.
8 (a) J. A. Ferreras, J.-S. Ryu, F. Di Lello, D. S. Tan and L. E. N.
Quadri, Nat. Chem. Biol., 2005, 1, 29–32; (b) R. V. Somu, H.
Boshoff, C. Qiao, E. M. Bennett, C. E. Barry III and C. C. Aldrich,
J. Med. Chem., 2006, 49, 31–34.
9 T. V. Inglesby, T. O0Toole, D. A. Henderson, J. G. Bartlett, M. S.
Ascher, E. Eitzen, A. M. Friedlander, J. Gerberding, J. Hauer, J.
Hughes, J. McDade, M. T. Osterholm, G. Parker, T. M. Perl, P. K.
Russell and K. Tonat, J. Am. Med. Assoc., 2002, 287, 2236–2252.
10 S. Cendrowski, W. MacArthur and P. Hanna, Mol. Microbiol.,
2004, 51, 407–417.
11 M. K. Wilson, R. J. Abergel, K. N. Raymond, J. E. L. Arceneaux and
B. R. Byers, Biochem. Biophys. Res. Commun., 2006, 348, 320–325.
12 R. J. Abergel, M. K. Wilson, J. E. L. Arceneaux, T. M. Hoette, R.
K. Strong, B. R. Byers and K. N. Raymond, Proc. Natl. Acad. Sci.
U. S. A., 2006, 103, 18499–18503.
13 B. F. Pfleger, J. Y. Lee, R. V. Somu, C. C. Aldrich, P. C. Hanna
and D. H. Sherman, Biochemistry, 2007, 46, 4147–4157.
14 M. X. Wu and K. A. W. Hill, Anal. Biochem., 1993, 211, 320–323.
URI: http://wrap.warwick.ac.uk/id/eprint/29337

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Actions (login required)

View Item View Item