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Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen
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Varsani, Arvind, Shepherd, Dionne N., Monjane, Aderito L., Owor, Betty E., Erdmann, Julia B., Rybicki, Edward P., Peterschmitt, Michel, Briddon, Rob W., Markham, Peter G., Oluwafemi, Sunday, Windram, Oliver P., Lefeuvre, Pierre, Lett, Jean-Michel and Martin, Darren P. (2008) Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. Journal of General Virology, Vol.89 (Pt.9). pp. 2063-2074. doi:10.1099/vir.0.2008/003590-0
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Official URL: http://dx.doi.org/10.1099/vir.0.2008/003590-0
Abstract
Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these - MSV-A causes severe disease in maize. Due primarily to their not being an obvious threat to agriculture, very little is known about the 'grass-adapted' MSV strains, MSV-B, -C, -D and -E. Since comparing the genetic diversities, geographical distributions and natural host ranges of MSV-A with the other MSV strains could provide valuable information on the epidemiology, evolution and emergence of MSV-A, we carried out a phylogeographical analysis of MSVs found in uncultivated indigenous African grasses. Amongst the 83 new MSV genomes presented here, we report the discovery of six new MSV strains (MSV-F to -K). The non-random recombination breakpoint distributions detectable with these and other available mastrevirus sequences partially mirror those seen in begomoviruses, implying that the forces shaping these breakpoint patterns have been largely conserved since the earliest geminivirus ancestors. We present evidence that the ancestor of all MSV-A variants was the recombinant progeny of ancestral MSV-B and MSV-G/-F variants. While it remains unknown whether recombination influenced the emergence of MSV-A in maize, our discovery that MSV-A variants may both move between and become established in different regions of Africa with greater ease, and infect more grass species than other MSV strains, goes some way towards explaining why MSV-A is such a successful maize pathogen.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QR Microbiology > QR355 Virology S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) | ||||
| Library of Congress Subject Headings (LCSH): | Corn -- Diseases and pests -- Africa, Sub-Saharan, Pathogenic microorganisms, Corn -- Phylogeny, Genetic recombination | ||||
| Journal or Publication Title: | Journal of General Virology | ||||
| Publisher: | Society for General Microbiology | ||||
| ISSN: | 0022-1317 | ||||
| Official Date: | September 2008 | ||||
| Dates: |
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| Volume: | Vol.89 | ||||
| Number: | Pt.9 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 2063-2074 | ||||
| DOI: | 10.1099/vir.0.2008/003590-0 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Research Foundation (South Africa), Carnegie Corporation of New York, PANNAR (Pty) Ltd., Wellcome Trust (London, England), Rockefeller Foundation, Canon Collins Trust for Southern Africa, University of Cape Town, France. Ministère de la recherche et de l'enseignement supérieur, CIRAD (Organization) |
Data sourced from Thomson Reuters' Web of Knowledge
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