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Use of a coronary heart disease simulation model to evaluate the costs and effectiveness of drugs for the prevention of heart disease
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Cooper, K., Davies, Robin P., Raftery, James, Professor and Roderick, Paul (2008) Use of a coronary heart disease simulation model to evaluate the costs and effectiveness of drugs for the prevention of heart disease. Journal of the Operational Research Society, Vol.59 (No.9). pp. 1173-1181. doi:10.1057/palgrave.jors.2602468 ISSN 0160-5682.
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Official URL: http://dx.doi.org/10.1057/palgrave.jors.2602468
Abstract
A discrete event simulation model of the patient pathways in the treatment of coronary heart disease (CHD) was used to quantify the health gains and costs associated with increasing secondary prevention drugs prescription for patients with CHD based on the level recommended in the National Service Framework for the UK. A Gompertz distribution was sampled for time to failure ( death or non-fatal heart attack). The time to failure was modified in relation to the reduced risk of failure for those on the relevant drugs. The results from the model were validated against national data. Increasing the levels of prescription of secondary prevention drugs to those patients with CHD might prevent 100 deaths per million population per year and cost an additional 4 pound million per million population per year. With cost per life year saved of 5520 pound, this appears good value for money compared with other health technologies.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Coronary heart disease -- Mathematical models, Coronary heart disease -- Treatment -- Cost effectiveness, Coronary heart disease -- Prevention | ||||
| Journal or Publication Title: | Journal of the Operational Research Society | ||||
| Publisher: | Palgrave Macmillan Ltd. | ||||
| ISSN: | 0160-5682 | ||||
| Official Date: | September 2008 | ||||
| Dates: |
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| Volume: | Vol.59 | ||||
| Number: | No.9 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 1173-1181 | ||||
| DOI: | 10.1057/palgrave.jors.2602468 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Centre for Health Outcomes Development |
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