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Persistent sodium current is a nonsynaptic substrate for long-term associative memory
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Nikitin, Eugeny S., Vavoulis, Dimitris V., Kemenes, Ildiko, Marra, Vincenzo, Pirger, Zsolt, Michel, Maximilian, Feng, Jianfeng, O'Shea, Michael, Benjamin, Paul R. and Kemenes, Gyoergy (2008) Persistent sodium current is a nonsynaptic substrate for long-term associative memory. Current Biology, Vol.18 (No.16). pp. 1221-1226. doi:10.1016/j.cub.2008.07.030 ISSN 0960-9822.
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Official URL: http://dx.doi.org/10.1016/j.cub.2008.07.030
Abstract
Although synaptic plasticity is widely regarded as the primary mechanism of memory [1], forms of nonsynaptic plasticity, such as increased somal or dendritic excitability or membrane potential depolarization, also have been implicated in learning in both vertebrate and invertebrate experimental systems [2-7]. Compared to synaptic plasticity, however, there is much less information available on the mechanisms of specific types of nonsynaptic plasticity involved in well-defined examples of behavioral memory. Recently, we have shown that learning-induced somal depolarization of an identified modulatory cell type (the cerebral giant cells, CGCs) of the snail Lymnaea stagnalis encodes information that enables the expression of long-term associative memory [8]. The Lymnaea CGCs therefore provide a highly suitable experimental system for investigating the ionic mechanisms of nonsynaptic plasticity that can be linked to behavioral learning. Based on a combined behavioral, electrophysiological, immunohistochemical, and,computer simulation approach, here we show that an increase of a persistent sodium current of this neuron underlies its delayed and persistent depolarization after behavioral single-trial classical conditioning. Our findings provide new insights into how learning-induced membrane level changes are translated into a form of long-lasting neuronal plasticity already known to contribute to maintained adaptive modifications at the network and behavioral level [8].
Item Type: | Journal Article | ||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QD Chemistry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Centre for Scientific Computing Faculty of Science, Engineering and Medicine > Science > Computer Science |
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Library of Congress Subject Headings (LCSH): | Sodium -- Physiological transport, Long-term memory, Neuroplasticity | ||||
Journal or Publication Title: | Current Biology | ||||
Publisher: | Cell Press | ||||
ISSN: | 0960-9822 | ||||
Official Date: | 26 August 2008 | ||||
Dates: |
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Volume: | Vol.18 | ||||
Number: | No.16 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 1221-1226 | ||||
DOI: | 10.1016/j.cub.2008.07.030 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Medical Research Council (Great Britain) (MRC), Engineering and Physical Sciences Research Council (EPSRC) |
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