Nikitin, Eugeny S., Vavoulis, Dimitris V., Kemenes, Ildiko, Marra, Vincenzo, Pirger, Zsolt, Michel, Maximilian, Feng, Jianfeng, O'Shea, Michael, 1947-, Benjamin, Paul R. and Kemenes, Gyoergy. (2008) Persistent sodium current is a nonsynaptic substrate for long-term associative memory. Current Biology, Vol.18 (No.16). pp. 1221-1226. ISSN 0960-9822

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Abstract

Although synaptic plasticity is widely regarded as the primary mechanism of memory [1], forms of nonsynaptic plasticity, such as increased somal or dendritic excitability or membrane potential depolarization, also have been implicated in learning in both vertebrate and invertebrate experimental systems [2-7]. Compared to synaptic plasticity, however, there is much less information available on the mechanisms of specific types of nonsynaptic plasticity involved in well-defined examples of behavioral memory. Recently, we have shown that learning-induced somal depolarization of an identified modulatory cell type (the cerebral giant cells, CGCs) of the snail Lymnaea stagnalis encodes information that enables the expression of long-term associative memory [8]. The Lymnaea CGCs therefore provide a highly suitable experimental system for investigating the ionic mechanisms of nonsynaptic plasticity that can be linked to behavioral learning. Based on a combined behavioral, electrophysiological, immunohistochemical, and,computer simulation approach, here we show that an increase of a persistent sodium current of this neuron underlies its delayed and persistent depolarization after behavioral single-trial classical conditioning. Our findings provide new insights into how learning-induced membrane level changes are translated into a form of long-lasting neuronal plasticity already known to contribute to maintained adaptive modifications at the network and behavioral level [8].

Item Type:	Journal Article
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QD Chemistry
Divisions:	Faculty of Science > Centre for Scientific Computing Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH):	Sodium -- Physiological transport, Long-term memory, Neuroplasticity
Journal or Publication Title:	Current Biology
Publisher:	Cell Press
ISSN:	0960-9822
Date:	26 August 2008
Volume:	Vol.18
Number:	No.16
Number of Pages:	6
Page Range:	pp. 1221-1226
Identification Number:	10.1016/j.cub.2008.07.030
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Medical Research Council (Great Britain) (MRC), Engineering and Physical Sciences Research Council (EPSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/29425

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