Stranges, Saverio, Dorn, Joan M., Donahue, Richard P., Browne, Richard W., Freudenheim, Jo L., Hovey, Kathleen M. and Trevisan, Maurizio (2008) Oxidation, type 2 diabetes, and coronary heart disease : a complex interaction - findings from a population-based study. Diabetes Care, Vol.31 (No.9). pp. 1864-1866. doi:10.2337/dc08-0558 ISSN 0149-5992.
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Abstract
OBJECTIVE - The purpose of this study was to analyze the interrelationship among oxidation, myocardial infarction (MI), and type 2 diabetes in a population-based case-control study of MI.
RESEARCH DESIGN AND METHODS - Participants were 1,709 individuals from western New York: 257 women and men with incident MI and 1,452 healthy control subjects (aged 35-70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was determined by self-reported history of medical diagnosis.
RESULTS - in multivariate analyses, there was no significant difference in TBARS levels between case and control subjects in both sexes. In subgroup analyses by diabetes status, diabetic subjects, regardless of MI status, exhibited significantly higher TBARS values than nondiabetic subjects. For diabetic women, TBARS values were 1.84 and 1.83 nmol/ml for case and control subjects, respectively. Values for nondiabetic women were 1.29 and 1.31 nmol/ml, respectively. In diabetic men, values were 1.65 and 1.97 nmol/ml for case and control subjects, respectively. Values for nondiabetic men were 1.36 and 1.36 nmol/ml, respectively.
CONCLUSIONS- Whereas type 2 diabetes maybe an important correlate of lipid peroxidation, clinical coronary heart disease may not.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QA Mathematics R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Oxidation, Non-insulin-dependent diabetes, Coronary heart disease, Multivariate analysis, Case-control method, Epidemiology -- Statistical methods |
| Journal or Publication Title: | Diabetes Care |
| Publisher: | American Diabetes Association |
| ISSN: | 0149-5992 |
| Official Date: | September 2008 |
| Dates: | Date Event September 2008 Published |
| Volume: | Vol.31 |
| Number: | No.9 |
| Number of Pages: | 3 |
| Page Range: | pp. 1864-1866 |
| DOI: | 10.2337/dc08-0558 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | National Institute on Alcohol Abuse and Alcoholism (U.S.) (NIAAA) |
| Grant number: | 5 P50 AA09802 (NIAAA) |
| URI: | https://wrap.warwick.ac.uk/29453/ |
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