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Isostructural replacement of zinc by cadmium in bacterial metallothionein

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Blindauer, Claudia A., Harrison, Mark D., Parkinson, J. A. (John A.), Robinson, N. J. (Nigel J.) and Sadler, P. J. (2008) Isostructural replacement of zinc by cadmium in bacterial metallothionein. In: 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, France, 19-22 May 2008. Published in: Metal Ions in Biology and Medicine, Vol.10 pp. 167-173. ISBN 978-2-7420-0714-1. ISSN 1257-2535.

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Abstract

The class II metallothionein SmtA from the cyanobacterium Synechococcus PCC 7942 plays a major role in providing tolerance to high levels of zinc as well as a lesser role in cadmium detoxification. We previously determined the NMR structure of Zn(4)SmtA [Blindauer et al., PNAS 2001, 98, 9593-9598] and assessed its zinc-binding dynamics. In the present report, we discuss the solution structure of cadmium-loaded SmtA and provide insight into the way in which cyanobacteria manage chemically similar toxic and essential metal ions. Comparisons of 3D structures and NMR data indicate that SmtA is able to accommodate either zinc or cadmium equally well. This work is not only relevant to understanding the biological role of bacterial metallothioneins, but also has implications for metalloprotein promiscuity and specificity.

Item Type: Conference Item (Paper)
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Zinc, Cadmium, Metallothionein, Metabolic detoxification, Metal ions
Journal or Publication Title: Metal Ions in Biology and Medicine
Publisher: John Libbey Eurotext
ISBN: 978-2-7420-0714-1
ISSN: 1257-2535
Editor: Collery, P and Maymard, I and Theophanides, T and Khassanova, L and Collery, T
Official Date: May 2008
Dates:
DateEvent
May 2008Published
Volume: Vol.10
Number of Pages: 7
Page Range: pp. 167-173
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Conference Paper Type: Paper
Title of Event: 10th International Symposium on Metal Ions in Biology and Medicine
Type of Event: Conference
Location of Event: Bastia, France
Date(s) of Event: 19-22 May 2008

Data sourced from Thomson Reuters' Web of Knowledge

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