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Isostructural replacement of zinc by cadmium in bacterial metallothionein
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Blindauer, Claudia A., Harrison, Mark D., Parkinson, J. A. (John A.), Robinson, N. J. (Nigel J.) and Sadler, P. J. (2008) Isostructural replacement of zinc by cadmium in bacterial metallothionein. In: 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, France, 19-22 May 2008. Published in: Metal Ions in Biology and Medicine, Vol.10 pp. 167-173. ISBN 978-2-7420-0714-1. ISSN 1257-2535.
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Abstract
The class II metallothionein SmtA from the cyanobacterium Synechococcus PCC 7942 plays a major role in providing tolerance to high levels of zinc as well as a lesser role in cadmium detoxification. We previously determined the NMR structure of Zn(4)SmtA [Blindauer et al., PNAS 2001, 98, 9593-9598] and assessed its zinc-binding dynamics. In the present report, we discuss the solution structure of cadmium-loaded SmtA and provide insight into the way in which cyanobacteria manage chemically similar toxic and essential metal ions. Comparisons of 3D structures and NMR data indicate that SmtA is able to accommodate either zinc or cadmium equally well. This work is not only relevant to understanding the biological role of bacterial metallothioneins, but also has implications for metalloprotein promiscuity and specificity.
| Item Type: | Conference Item (Paper) | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Zinc, Cadmium, Metallothionein, Metabolic detoxification, Metal ions | ||||
| Journal or Publication Title: | Metal Ions in Biology and Medicine | ||||
| Publisher: | John Libbey Eurotext | ||||
| ISBN: | 978-2-7420-0714-1 | ||||
| ISSN: | 1257-2535 | ||||
| Editor: | Collery, P and Maymard, I and Theophanides, T and Khassanova, L and Collery, T | ||||
| Official Date: | May 2008 | ||||
| Dates: |
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| Volume: | Vol.10 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 167-173 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 10th International Symposium on Metal Ions in Biology and Medicine | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Bastia, France | ||||
| Date(s) of Event: | 19-22 May 2008 |
Data sourced from Thomson Reuters' Web of Knowledge
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