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Mathematical models of energy homeostasis
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Pattaranit, Ratchada and Berg, Hugo van den (2008) Mathematical models of energy homeostasis. Journal of The Royal Society Interface, Volume 5 (Number 27). pp. 1119-1135. doi:10.1098/rsif.2008.0216
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Official URL: http://dx.doi.org/10.1098/rsif.2008.0216
Abstract
Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Mathematics Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC) |
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| Library of Congress Subject Headings (LCSH): | Homeostasis -- Mathematical models, Diabetes, Obesity, Insulin resistance, Glucose -- Physiological effect, Metabolism | ||||
| Journal or Publication Title: | Journal of The Royal Society Interface | ||||
| Publisher: | The Royal Society Publishing | ||||
| ISSN: | 1742-5689 | ||||
| Official Date: | 6 October 2008 | ||||
| Dates: |
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| Volume: | Volume 5 | ||||
| Number: | Number 27 | ||||
| Number of Pages: | 17 | ||||
| Page Range: | pp. 1119-1135 | ||||
| DOI: | 10.1098/rsif.2008.0216 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Thailand, University of Warwick. Molecular Organisation and Assembly in Cells, Engineering and Physical Sciences Research Council (EPSRC), Sixth Framework Programme (European Commission) (FP6) |
Data sourced from Thomson Reuters' Web of Knowledge
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