Pattaranit, Ratchada and Berg, Hugo van den, 1968- (2008) Mathematical models of energy homeostasis. Journal of The Royal Society Interface, Volume 5 (Number 27). pp. 1119-1135. ISSN 1742-5689

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Abstract

Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.

Item Type:	Journal Item
Subjects:	Q Science > QA Mathematics Q Science > QP Physiology
Divisions:	Faculty of Science > Mathematics Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
Library of Congress Subject Headings (LCSH):	Homeostasis -- Mathematical models, Diabetes, Obesity, Insulin resistance, Glucose -- Physiological effect, Metabolism
Journal or Publication Title:	Journal of The Royal Society Interface
Publisher:	The Royal Society Publishing
ISSN:	1742-5689
Official Date:	6 October 2008
Volume:	Volume 5
Number:	Number 27
Number of Pages:	17
Page Range:	pp. 1119-1135
Identification Number:	10.1098/rsif.2008.0216
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Thailand, University of Warwick. Molecular Organisation and Assembly in Cells, Engineering and Physical Sciences Research Council (EPSRC), Sixth Framework Programme (European Commission) (FP6)
URI:	http://wrap.warwick.ac.uk/id/eprint/29507

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