Mathematical models of energy homeostasis
Pattaranit, Ratchada and Berg, Hugo van den, 1968- (2008) Mathematical models of energy homeostasis. Journal of The Royal Society Interface, Vol.5 (No.27). pp. 1119-1135. ISSN 1742-5689Full text not available from this repository.
Official URL: http://dx.doi.org/10.1098/rsif.2008.0216
Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.
|Item Type:||Journal Item|
|Divisions:||Faculty of Science > Mathematics
Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
|Journal or Publication Title:||Journal of The Royal Society Interface|
|Publisher:||The Royal Society Publishing|
|Date:||6 October 2008|
|Number of Pages:||17|
|Page Range:||pp. 1119-1135|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Thai government, MOAC Doctoral Training Centre at Warwick University|
Actions (login required)