Hemming, Karla, Colver, Allan, Hutton, Jane L., Kurinczuk, Jennifer J. and Pharoah, Peter O. D.. (2008) The influence of gestational age on severity of impairment in spastic cerebral palsy. Journal of Pediatrics, Volume 153 (Number 2). pp. 203-208. ISSN 0022-3476

Full text not available from this repository.

Abstract

Objective: To investigate the association between severity of impairment and gestational age in unilateral and bilateral spastic cerebral palsy, and to determine whether the influence of gestational age is independent of deviations from optimal birth weight. Study design: The study group was a United Kingdom cohort of 4772 cases of spastic cerebral palsy born between 1960 and 1997, with information on birth demographics and severity of impairment. Generalized additive models were used to determine the proportions of cases severely impaired, by gestational age, and to determine whether gestational age or deviations from optimal birth weight better predicts severity of impairment. Results: For unilateral spastic cerebral palsy, the proportions of severe impairments did not vary with gestational age. In contrast, for bilateral spastic cerebral palsy, the proportions of severe motor or cognitive impairments increased with increasing gestational age (e.g., from 20% to 50% between weeks 30 and 40 for cognitive impairment). For spastic cerebral palsy, gestational age is at least as good as deviation from optimal birth weight in predicting severity. Conclusions: The severity of impairment increases with increasing gestational age in bilateral spastic cerebral palsy. This suggests differing etiologies in term and preterm infants and supports the theory that the developing brain is better able to compensate after a cerebral insult.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics
Divisions:	Faculty of Science > Statistics
Library of Congress Subject Headings (LCSH):	Cerebral palsy, Gestational age, Cohort analysis, Birth weight
Journal or Publication Title:	Journal of Pediatrics
Publisher:	Elsevier
ISSN:	0022-3476
Date:	August 2008
Volume:	Volume 153
Number:	Number 2
Number of Pages:	6
Page Range:	pp. 203-208
Identification Number:	10.1016/j.jpeds.2008.02.041
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
References:	1. Jarvis S, Glinianaia SV, Torrioli MG, Platt MJ, Miceli M, Jouk PS, et al. Cerebral palsy and intrauterine growth in single births: the European Collaborative Study. Lancet 2003;362:1106-11. 2. Glinianaia SV, Jarvis S, Topp M, Guillem P, Platt MJ, Pearce MS, et al. Intrauterine growth and cerebral palsy in twins: a European multicenter study. Twin Res Hum Genet 2006;9:460-6. 3. Jarvis S, Glinianaia SV, Arnaud C, Fauconnier J, Johnson A, McManus V, et al. Case sex and severity in cerebral palsy varies with intrauterine growth. Arch Dis Child 2005;90:474-9. 4. Jarvis S, Glinianaia SV, Blair E. Cerebral palsy and intrauterine growth. Clin Perinatol 2006;33:285-300. 5. Blair E, Stanley F. Intrauterine growth and spastic cerebral palsy. Am J Obstet Gynecol 1990;162:229-37. 6. Uvebrant P, Hagberg G. Intrauterine growth in children with cerebral palsy. Acta Paediatr 1992;81:407-12. 7. Foley J. Birth weight ratio and cerebral palsy. Early Hum Dev 1995;40:145-56. 8. Topp M, Langhoff-Roos J, Uldall P, Kristensen J. Intrauterine growth and gestational age in preterm infants with cerebral palsy. Early Hum Dev 1996;44:27-36. 9. Hemming K, Hutton JL, Bonellie S, Kurinczuk JJ. Intrauterine growth and survival in cerebral palsy. Arch Dis Child Fetal Neonatal Ed 2007;2:F121-6. 10. Stanley F, Blair E, Alberman E. In: Cerebral Palsy: Epidemiology and Causal Pathways. MacKeith Press; 2000. p.20. 11. Topp M, Huuson LD, Langhoff-Roos J, Delhumeau C, Hutton JL, Dolk H. Multiple birth and cerebral palsy in Europe: a multicenter study. Acta Obstet Gynecol Scand 2004;83:548-53. 12. Tucker J, McGuire W. ABC of preterm birth: epidemiology of preterm birth. BMJ 2004;329:675-8. 13. Himmelmann K, Beckung E, Hagberg G, Uvebrant P. Gross and fine motor function and accompanying impairments in cerebral palsy. Dev Med Child Neurol 2006;48:417-23. 14. Andersen GL, Irgens LM, Haagaas I, Skranes JS, Merberg AE, Vik T. Cerebral palsy in Norway: prevalence, subtypes and severity. Eur J Paediatr Neurol 2007;12:4-13. 15. Hutton JL, Pharoah PO, Cooke WI, Stevenson RC. Differential effects of preterm birth and small gestational age on cognitive and motor development. Arch Dis Child 1997;76:75-81. 16. Hemming K, Hutton JL, Glinianaia SV, Jarvis S, Platt MJ. Differences between European birth weight standards: impact on classification for small for gestational age. Dev Med Child Neurol 2006;48:906-12. 17. Cans C, Dolk H, Platt MJ, Colver A, Prasauskiene A, Krägeloh-Mann I. Recommendations from the SCPE collaborative group for defining and classifying cerebral palsy. Dev Med Child Neurol 2007;109:35-8. 18. Hemming K, Hutton JL, Colver A, Platt MJ. Regional variation in survival of people with cerebral palsy in the United Kingdom. Pediatrics 2005;116:1383-90. 19. Surman G, Bonellie S, Chalmers J, Colver A, Dolk H, Hemming K, et al. UKCP: a collaborative network of cerebral palsy registers in the United Kingdom. J Public Health (Oxf) 2006;28:148-56. 20. Cans C. Surveillance of Cerebral Palsy in Europe (SCPE): a collaboration of cerebral palsy surveys and registers. Dev Med Child Neurol 2000;42:816-24. 21. Scottish Health Services Common Services Agency. Scotland: Birth Weight, Head Circumference and Length for Gestational Age. Edinburgh, UK: Scottish Health Services Common Services Agency; 1990. 22. Hastie T, Tibshirani R. Generalized Additive Models. London: Chapman & Hall; 1990. 23. Pharoah POD, Cooke T, Johnson MA, King R, Mutch L. Epidemiology of cerebral palsy in England and Scotland. Arch Dis Child 1998;79:F21-5. 24. Staudt M. Reorganization of the developing human brain after early lesions. Dev Med Child Neurol 2007;49:564–4. 25. Muter V, Taylor S, Vargha-Khadem F. A longitudinal study of early intellectual development in hemiplegic children. Neuropsychologia 1997;35:289-98. 26. Maegaki Y, Maeoka Y, Ishii S, Eda I, Ohtagaki A, Kitahara T, et al. Central motor reorganization in cerebral palsy patients with bilateral cerebral lesions. Pediatr Res 1999;45:559-67. 27. Stuadt M, Garloff C, Grodd W, Holthausen H, Niemann G, Krageloh-Mann I. Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol 2004;56:854-63. 28. Hutton JL, Pharoah POD. Effect of cognitive, motor and sensory disabilities on survival in cerebral palsy. Arch Dis Child 2002;86:84-9. 29. Bodeau-Livinec F, Surman G, Kaminski M, Wilkinson AR, Ancel PY, Kurinczuk JJ. Recent trents in visual impairment and blindness in the UK. Arch Dis Child 2007;92:1099-104.
URI:	http://wrap.warwick.ac.uk/id/eprint/29576

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item