MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level
Valsamakis, Georgios, Jones, A., Chetty, R., McTernan, P. G. (Philip G.), Boutsiadis, A., Barnett, A. H., Banerjee, A. K. and Kumar, Sudhesh. (2008) MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level. Current Medical Research and Opinion, Vol.24 (No.7). pp. 1853-1860. ISSN 0300-7995Full text not available from this repository.
Official URL: http://dx.doi.org/10.1185/03007990802185757
Objective: To compare associations between anteroposterior (AP) diameter or sagittal abdominal diameter a measure of total central fat, and visceral fat alone with the metabolic syndrome as defined by ATPIII criteria.
Research design and methods: Twenty-four Caucasian male with type 2 diabetes and 24 non-diabetic Caucasian male subjects [body mass index (BMI) (+/-SD): 32.23 7.52 kg/m(2), age (+/-SD): 51.35 +/- 13.80 years] were studied by magnetic resonance imaging (MRI) scan to measure central fat at L4-L5 level. The visceral and total central adipose tissue was calculated in cm(2) and total sagittal MRI diameter and visceral sagittal MRI diameters in cm. Components of the ATPIII definition of the metabolic syndrome and circulating adipocytokine concentrations were also measured.
Results: MRI total sagittal abdominal diameter was positively associated with waist circumference in controls (r= 0.62, p = 0.007) and in diabetic subjects (r= 0.81, p< 0.001). Binary logistic regression analysis showed that MRI-calculated total sagittal diameter (r= 0.61, p= 0.002) was a more significant predictor of the adverse metabolic profile of the metabolic syndrome than MRI-assessed visceral fat. Receiver operating characteristic curves revealed that MRI-calculated total sagittal diameter most effectively identified subjects with the metabolic syndrome.
Conclusions: MRI-calculated total sagittal abdominal diameter is a non-validated MRI method that predicts the adverse metabolic profile of the ATPIII definition of the metabolic syndrome. Antero-posterior fat is a dimension of central fat that seems to be more closely associated with cardiovascular risk compared to visceral fat.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Current Medical Research and Opinion|
|Official Date:||July 2008|
|Number of Pages:||8|
|Page Range:||pp. 1853-1860|
|Access rights to Published version:||Restricted or Subscription Access|
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