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Regulation of matrix metalloproteinases (MMP)-2/-9 expression in eosinophilic chronic rhinosinusitis - Cell culture by interleukin-5 and-13?
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Sauter, Alexander, Stern-Straeter, Jens, Sodha, Selina, Hoermann, Karl and Naim, Ramin. (2008) Regulation of matrix metalloproteinases (MMP)-2/-9 expression in eosinophilic chronic rhinosinusitis - Cell culture by interleukin-5 and-13? In Vivo, Vol.22 (No.4). pp. 415-421. ISSN 0258-851X
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Official URL: http://iv.iiarjournals.org/content/22/4/415.abstra...
Abstract
Background: Eosinophils are a prominent immunological feature of chronic rhinosinusitis (CRS). Cytokines in the respiratory mucosa may be the key to upper airway pathophysiology. Matrix metalloproteinases (MMP) represent an entire group of Zn2+ dependent endopeptidases with the potential to alter the extracellular matrix (ECM). In this study epithelial cultures of CRS were treated with interleukin (IL)-5 or IL-13 and subsequent levels of metalloproteinases were determined. Materials and Methods: The cells for CRS culture were obtained from patients undergoing functional endoscopic sinus surgery. After 8-72 hours incubation with 0.2-0.4 ng/ml IL-5 or 3-6 ng/ml IL-13, the expression of the MMP-2 and -9 in the CRS cultures was analysed. Results: After 72 hours incubation with IL-5, the relative levels of MMP-2 showed no significant alteration in protein expression in comparison with the control groups. Incubation with IL-13 revealed a statistically insignificant decrease of the relative MMP-9 expression in ECRS compared to the control group (p>0.1). Conclusion: Alterations of MMP-2 and -9 expression may play a role in ECRS, but the association with IL-5 and IL-13 remains unclear.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | In Vivo |
| Publisher: | International Institute of Anticancer Research |
| ISSN: | 0258-851X |
| Date: | July 2008 |
| Volume: | Vol.22 |
| Number: | No.4 |
| Number of Pages: | 7 |
| Page Range: | pp. 415-421 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/29677 |
Data sourced from Thomson Reuters' Web of Knowledge
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