Recognition of acetylated oligosaccharides by human L-ficolin
Krarup, Anders, Mitchell, Daniel Anthony and Sim, Robert B.. (2008) Recognition of acetylated oligosaccharides by human L-ficolin. Immunology Letters, Vol.118 (No.2). pp. 152-156. ISSN 0165-2478Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.imlet.2008.03.014
The complement system is a protein cascade capable of neutralizing invading pathogens. One of its activation pathways is the lectin pathway which is dependent on the binding of MBL or the ficolins. The specificity of L-ficolin binding has been investigated previously and it was observed that binding is dependent on acetyl groups. If this was the only requirement this would enable L-ficolin to bind to most mammalian glycosylations since they contain acetylated monosaccharides. To investigate this further L-ficolin was subjected to glycan-array analysis in which L-ficolin binding to 279 different glycans was investigated. Few of these bound L-ficolin above background level but clear structural requirements were discovered. (c) 2008 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology|
|Divisions:||Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Immunology Letters|
|Official Date:||30 June 2008|
|Number of Pages:||5|
|Page Range:||pp. 152-156|
|Access rights to Published version:||Restricted or Subscription Access|
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