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The origins of replication of granuloviruses
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Hilton, Sally and Winstanley, Doreen (2008) The origins of replication of granuloviruses. Archives of Virology, Volume 153 (Number 8). pp. 1527-1535. doi:10.1007/s00705-008-0148-0
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Official URL: http://dx.doi.org/10.1007/s00705-008-0148-0
Abstract
The genomes of eight granuloviruses (GVs), have been analyzed for the presence of homologous regions (hrs) that may act as origins of replication. Thirteen 74-76-bp palindromes within 11 hrs have previously been identified in the Cydia pomonella GV (CpGV) genome and found to replicate in an infection-dependent DNA replication assay. We report a further palindrome within one of the hrs, which was found to replicate, bringing the total to 14 palindromes. We also report imperfect palindromes, with similar 13-bp end sequences to the CpGV palindromes, within the Adoxophyes orana GV, Cryptophlebia leucotreta GV (CrleGV), Choristoneura occidentalis GV and Phthorimaea operculella GV genomes. No hrs were detected in Agrotis segetum GV, and no additional hrs or palindromes, other than those published, were detected in the Plutella xylostella GV and Xestia c-nigrum GV genomes. Several putative hrs from the GVs were tested for replication in C. pomonella cells using a CpGV-dependent replication assay. Two CrleGV hrs were found to replicate at a low level.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) | ||||
| Library of Congress Subject Headings (LCSH): | Baculoviruses, Viruses -- Reproduction | ||||
| Journal or Publication Title: | Archives of Virology | ||||
| Publisher: | Springer Wien | ||||
| ISSN: | 0304-8608 | ||||
| Official Date: | August 2008 | ||||
| Dates: |
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| Volume: | Volume 153 | ||||
| Number: | Number 8 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 1527-1535 | ||||
| DOI: | 10.1007/s00705-008-0148-0 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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