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Probabilistic framework for gene expression clustering validation based on Gene Ontology and graph theory
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Yuan, Yinyin and Li, Chang-Tsun (2008) Probabilistic framework for gene expression clustering validation based on Gene Ontology and graph theory. In: 33rd IEEE International Conference on Acoustics, Speech and Signal Processing, Las Vegas, NV, Mar 30-Apr 04, 2008. Published in: IEEE International Conference on Acoustics, Speech and Signal Processing. Proceedings, Vol.1-12 pp. 625-628. ISBN 978-1-4244-1483-3. doi:10.1109/ICASSP.2008.4517687 ISSN 1520-6149.
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Abstract
Based on the correlation between expression and ontology-driven gene similarity, we incorporate functional annotations into gene expression clustering validation. A probabilistic framework is proposed to accommodate incomplete annotations, after establishing a new term-term distance measure based on graph theory. Comprehensive evaluations are performed on six clustering algorithms. This study is the first to explore a robust quantitative functional. relationship between clusters of genes. Such indices assess clustering quality in terms of consistency of annotation information and serve as new tools for combining biological knowledge with experimental data.
Item Type: | Conference Item (UNSPECIFIED) | ||||
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Subjects: | Q Science > QA Mathematics Q Science > QH Natural history > QH426 Genetics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||
Library of Congress Subject Headings (LCSH): | Gene expression, Hypergeometric distribution, Graph theory, Cluster analysis | ||||
Series Name: | International Conference on Acoustics Speech and Signal Processing (ICASSP) | ||||
Journal or Publication Title: | IEEE International Conference on Acoustics, Speech and Signal Processing. Proceedings | ||||
Publisher: | IEEE | ||||
ISBN: | 978-1-4244-1483-3 | ||||
ISSN: | 1520-6149 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.1-12 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 625-628 | ||||
DOI: | 10.1109/ICASSP.2008.4517687 | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Title of Event: | 33rd IEEE International Conference on Acoustics, Speech and Signal Processing | ||||
Type of Event: | Conference | ||||
Location of Event: | Las Vegas, NV | ||||
Date(s) of Event: | Mar 30-Apr 04, 2008 |
Data sourced from Thomson Reuters' Web of Knowledge
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